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l-Arginine Uptake by Cationic Amino Acid Transporter Promotes Intra-Macrophage Survival of Leishmania donovani by Enhancing Arginase-Mediated Polyamine Synthesis
The survival of intracellular protozoan parasite, Leishmania donovani, the causative agent of Indian visceral leishmaniasis (VL), depends on the activation status of macrophages. l-Arginine, aExpand
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Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm
  • S. Roy, C. Mandal
  • Biology, Medicine
  • PLoS neglected tropical diseases
  • 1 August 2016
Background Leishmania donovani, belonging to a unicellular protozoan parasite, display the differential level of linkage-specific sialic acids on their surface. Sialic acids bindingExpand
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Synergistic Effects of Two Probiotic Bacteria on Growth, Biochemical, and Immunological Responses of Litopenaeus vannamei (Boone, 1931)
The beneficial effects of two probiotic bacteria, Bacillus licheniformis and Bacillus megaterium, on growth, biochemical, and immunological responses of Litopenaeus vannamei (Boone, 1931) wereExpand
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Integrity of the actin cytoskeleton of host macrophages is essential for Leishmania donovani infection.
Visceral leishmaniasis is a vector-borne disease caused by an obligate intracellular protozoan parasite Leishmania donovani. The molecular mechanism involved in internalization of Leishmania isExpand
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Sialic acids siglec interaction: A unique strategy to circumvent innate immune response by pathogens
Sialic acids (Sias) are nine-carbon keto sugars primarily present on the terminal residue of cell surface glycans. Sialic acid binding immunoglobulins (Ig)-like lectins (siglecs) are generallyExpand
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Mahanine exerts in vitro and in vivo antileishmanial activity by modulation of redox homeostasis
Earlier we have established a carbazole alkaloid (mahanine) isolated from an Indian edible medicinal plant as an anticancer agent with minimal effect on normal cells. Here we report for the firstExpand
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Statin-induced chronic cholesterol depletion inhibits Leishmania donovani infection: Relevance of optimum host membrane cholesterol.
Leishmania are obligate intracellular protozoan parasites that invade and survive within host macrophages leading to leishmaniasis, a major cause of mortality and morbidity worldwide, particularlyExpand
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Deprivation of L-Arginine Induces Oxidative Stress Mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine Pathway
The growth and survival of intracellular parasites depends on the availability of extracellular nutrients. Deprivation of nutrients viz glucose or amino acid alters redox balance in mammalian cellsExpand
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Withanolide D, carrying the baton of Indian rasayana herb as a lead candidate of antileukemic agent in modern medicine.
During cancer, immune system gets suppressed due to developing malignancy and anticancer drugs used. Therefore, an ideal chemotherapeutic agent would have both immuno-stimulatory and cancer cellExpand
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IN VITRO ANTHELMINTIC EFFECTS OF SENNA OCCIDENTALIS (L.) LINK (LEGUMINOSAE) ON RAT TAPEWORM HYMENOLEPIS DIMINUTA
Objective: This study was conducted to evaluate the anthelmintic activity of ethanolic leaf extract of Senna occidentalis on rat tapeworm Hymenolepis diminuta . Methods: Adult H. diminuta worms wereExpand
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