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Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver…
Findings indicate a genetic predisposition to the metabolism of irinotecan, suggesting that patients with low UGT1A1 activity, such as those with Gilbert's syndrome, may be at an increased risk for irinOTecan toxicity.
Isolation and long-term culture of human preantral follicles.
An enzymatic method for dissociation of intact follicles from the hamster ovary: histological and quantitative aspects.
An enzymatic method was developed to collect intact follicles at different stages of development from cyclic hamsters to study ovarian folliculogenesis under various circumstances and offers an improved method to study the factors responsible for the growth and the differentiation of small preantral follicles in the mammalian ovary.
A cytotaxonomic survey of the Pteridophyta of Australia
A cytotaxonomic survey of the ferns and fern allies of Australia (including Lord Howe Island) is presented, finding a number of species-complexes has been found and further chromosome counts added to intercontinental species complexes.
Requirement for follicle-stimulating hormone action in the formation of primordial follicles during perinatal ovarian development in the hamster.
Results provide the first direct evidence that FSH action during fetal ovarian development is critical for the onset of primordial follicle formation and shortening the postnatal duration of eCG exposure reduced the degree of reversal.
Ovarian transforming growth factor-beta (TGF-beta) receptors: in-vitro effects of follicle stimulating hormone, epidermal growth factor and TGF-beta on receptor expression in human preantral…
The shift in TbetaR-I and -II from transmembrane to soluble fraction after menopause indicates that the endocrine milieu provided by the granulosa cells positively influences receptor induction in the membrane and, hence, the biological action of TGF-beta.
Purification and properties of an L-asparaginase from Cylindrocarpon obtusisporum MB-10.
Metal ions, such as Zn2+, Fe2+, Cu2+, Hg2+ and Ni2+ potentially inhibited the enzyme activity, while metal chelators like EDTA, CN-, cysteine, etc., enhanced the activity indicating that the enzyme was not a metalloprotein.
Constitutive expression of a small heat‐shock protein confers cellular thermotolerance and thermal protection to the photosynthetic apparatus in cyanobacteria
Typhoid fever complicated by intestinal perforation: a persisting fatal disease requiring surgical management.
- T. Butler, J. Knight, S. Nath, P. Speelman, S. Roy, M. A. Azad
- MedicineReviews of infectious diseases
- 1 March 1985
It is indicated that intestinal perforation persists as a major cause of death in cases of typhoid fever in developing countries in the antibiotic era and that surgical treatment with use of antibiotic therapy is optimal for this complication.
Transforming growth factor-beta receptor type II expression in the hamster ovary: cellular site(s), biochemical properties, and hormonal regulation.
Results provide the first direct evidence for the presence of a functional T beta RII in the ovary, which is critically and temporally influenced by gonadotropins and ovarian steroid hormones.