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Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain
Despite increasing evidence of oxidative stress in the pathophysiology of autism, most studies have not evaluated biomarkers within specific brain regions, and the functional consequences ofExpand
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Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
Research into the metabolic phenotype of autism has been relatively unexplored despite the fact that metabolic abnormalities have been implicated in the pathophysiology of several otherExpand
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Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome
Autism spectrum disorder (ASD) affects a significant number of individuals worldwide with the prevalence continuing to grow. It is becoming clear that a large subgroup of individuals with ASDExpand
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Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
Butyrate (BT) is a ubiquitous short-chain fatty acid (SCFA) principally derived from the enteric microbiome. BT positively modulates mitochondrial function, including enhancing oxidativeExpand
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Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism
The modulation of the redox microenvironment is an important regulator of immune cell activation and proliferation. To investigate immune cell redox status in autism we quantified the intracellularExpand
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Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study
Gastrointestinal (GI) symptoms are prevalent in autism spectrum disorder (ASD) but the pathophysiology is poorly understood. Imbalances in the enteric microbiome have been associated with ASD and canExpand
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Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
We sought to determine whether high-dose folinic acid improves verbal communication in children with non-syndromic autism spectrum disorder (ASD) and language impairment in a double-blind placeboExpand
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Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines
Propionic acid (PPA) is a ubiquitous short-chain fatty acid, which is a major fermentation product of the enteric microbiome. PPA is a normal intermediate of metabolism and is found in foods, eitherExpand
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Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups
Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in autism spectrum disorder (ASD). They disrupt the transportation of folate across the blood-brain barrier by binding to the FRα.Expand
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The Frequency of Polymorphisms affecting Lead and Mercury Toxicity among Children with Autism
Individual risk of developmental neurotoxicity with exposure to environmentally relevant levels of lead and mercury is likely to be determined by genetic susceptibility factors as well as additiveExpand
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