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Consistent resting-state networks across healthy subjects
- J. Damoiseaux, S. Rombouts, C. Beckmann
- Psychology, BiologyProceedings of the National Academy of Sciences
- 12 September 2006
Findings show that the baseline activity of the brain is consistent across subjects exhibiting significant temporal dynamics, with percentage BOLD signal change comparable with the signal changes found in task-related experiments.
Toward discovery science of human brain function
- B. Biswal, M. Mennes, M. Milham
- Biology, PsychologyProceedings of the National Academy of Sciences
- 9 March 2010
A universal architecture of positive and negative functional connections, as well as consistent loci of inter-individual variability are demonstrated, which demonstrate that independent R-fMRI datasets can be aggregated and shared.
Reduced resting-state brain activity in the "default network" in normal aging.
This work examined the functional properties of brain networks based on spontaneous fluctuations within brain systems using functional magnetic resonance imaging to hypothesized that functional connectivity of intrinsic brain activity in the "default-mode" network (DMN) is affected by normal aging and that this relates to cognitive function.
Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study
- S. Rombouts, F. Barkhof, R. Goekoop, C. Stam, P. Scheltens
- Biology, PsychologyHuman brain mapping
- 1 December 2005
Altered activity in the default mode network may act as an early marker for AD pathology, suggesting that MCI is a transitional state between healthy aging and dementia and with the proposed early changes in MCI in the posterior cingulate cortex and precuneus.
What motivates the adolescent? Brain regions mediating reward sensitivity across adolescence.
- Linda van Leijenhorst, K. Zanolie, C. S. van Meel, P. Westenberg, S. Rombouts, E. Crone
- Psychology, BiologyCerebral cortex
This study shows that in anticipation of uncertain outcomes, the anterior insula is more active in adolescents compared with young adults and that the ventral striatum shows a reward-related peak in middle adolescence, whereas young adults show orbitofrontal cortex activation to omitted reward.
Adolescent risky decision-making: Neurocognitive development of reward and control regions
Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease
Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity
Evidence is presented of AD-induced changes in global brain functional connectivity specifically affecting long-distance connectivity, which supports the anterior-posterior disconnection theory and its role in AD.
Cortico‐hippocampal communication by way of parallel parahippocampal‐subicular pathways
It is concluded that the simple traditional view of the entorhinal cortex as simply the input and output structure of the hippocampus needs to be modified and the existence of two parallel pathways through the hippocampal memory system, arising from the perirhinal and postrhinal cortex is indicated.
Whole Brain Resting-State Analysis Reveals Decreased Functional Connectivity in Major Depression
Recently, both increases and decreases in resting-state functional connectivity have been found in major depression. However, these studies only assessed functional connectivity within a specific…