Skip to search formSkip to main contentSkip to account menu
The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human.
  • S. Roffey, S. Cole, N. Wood
  • Biology, Chemistry
    Drug metabolism and disposition: the biological…
  • 1 June 2003
TLDR
Repeat-dose toxicology studies in mouse, rat, and dog have demonstrated that induction of cytochrome P450 by voriconazole (autoinduction of metabolism) is responsible for the decreased exposure in these species.
View on PubMed
Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients.
TLDR
Voriconazole concentrations in the cerebrospinal fluid of immunocompetent guinea pigs and patients with invasive fungal infections are characterized and the ratio of CSF to plasma total and free drug concentration is determined.
View on PubMed
What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs
TLDR
Overall, mean recovery was greater in rats and dogs than in humans, and absolute recovery in humans should not be used as a major decision criteria as to whether a radiolabeled study has met its objectives.
View on Taylor & Francis
Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog
TLDR
UK-343,664 is a novel potent and selective PDE5 inhibitor that was in agreement with in vitro metabolism rates in hepatic microsomes and resulted in a longer elimination half-life in rat than dog.
View on Taylor & Francis
Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man
TLDR
The species' variation in pharmacokinetic parameters was related allometrically when plasma protein binding was taken in to account, Hence, active hepatic or renal clearance processes for this compound were conserved across species.
View on Taylor & Francis
Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: A rationale for long-lived plasma radioactivity
TLDR
Data indicate that this metabolite results from the oxadiazole ring-cleavage-producing oxamic acid, oxamide and oxalic acid, and was identified as the long-lived radioactivity which was observed in dog plasma.
View on Taylor & Francis
The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier.
View on PubMed
Fluorescence determination of sulphobutylether-beta-cyclodextrin in human plasma by size exclusion chromatography with inclusion complex formation.
View on PubMed
Nonlinear oral pharmacokinetics of the alpha-antagonist 4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-[4-(morpholinocarbonyl)-perhydro-1,4-diazepin-1-yl]quinoline in humans: use of preclinical data to…
TLDR
It is considered that P-gp acts as a saturable absorption barrier to UK-294,315, slowing the rate of absorption at low doses, and is responsible for the observed nonlinearity in oral disposition in humans.
View on PubMed
Hepatic peroxisomal and microsomal enzyme induction by citral and linalool in rats.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License