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Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
TLDR
The results provide evidence of how a naturally occurring genetic variation of the oxytocin receptor relates to both empathy and stress profiles and suggest that AA/AG individuals displayed higher physiological and dispositional stress reactivity than GG individuals.
Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning.
TLDR
It is proposed that the CS evokes EPSPs at sensory input synapses onto LA pyramidal neurons, and that the US strongly depolarizes these same LA neurons, which induce LTP-like changes that store memories during fear conditioning.
The influence of stress hormones on fear circuitry.
TLDR
This work discusses how stress and the endocrine mediators of the stress response influence the morphological and electrophysiological properties of neurons in brain areas that are crucial for fear-conditioning processes, including the amygdala, hippocampus, and prefrontal cortex.
The Group I Metabotropic Glutamate Receptor mGluR5 Is Required for Fear Memory Formation and Long-Term Potentiation in the Lateral Amygdala
TLDR
The results of this study indicate that mGluR5 in the LA plays a crucial role inFear conditioning and in plasticity at synapses involved in fear conditioning.
Intra-Amygdala Blockade of the NR2B Subunit of the NMDA Receptor Disrupts the Acquisition But Not the Expression of Fear Conditioning
TLDR
The present experiments examined the effects of selective blockade of the NR2B subunit of the NMDA receptor in LA using the selective antagonist ifenprodil, and found that the effects are attributable to a disruption of fear learning rather than a disruptions of memory consolidation.
Pavlovian Fear Conditioning Regulates Thr286 Autophosphorylation of Ca2+/Calmodulin-Dependent Protein Kinase II at Lateral Amygdala Synapses
TLDR
The results of these experiments provide the first comprehensive view of the role of CaMKII in the amygdala during fear conditioning.
Memory consolidation of Pavlovian fear conditioning requires nitric oxide signaling in the lateral amygdala
TLDR
The findings suggest that NO signaling is an important component of memory formation of auditory fear conditioning, possibly as a retrograde signal that participates in presynaptic aspects of plasticity in the LA.
Phosphorylation of ERK/MAP kinase is required for long-term potentiation in anatomically restricted regions of the lateral amygdala in vivo.
TLDR
It is demonstrated that ERK/MAPK activation is necessary for synaptic plasticity in anatomically defined regions of the LA, in vivo, and intra-LA infusion of U0126, an inhibitor of ERk/ MAPK activation, impairs LTP at thalamo-LA input synapses.
Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects
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