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Antiprotozoal activities of Colombian plants.
TLDR
The methylene chloride extract of leaves from C. scoparioides showed a selectivity index in the same range that the one of the Glucantime control, and several of the active leishmanicidal plants are traditionally used against leish maniasis by the population of the concerned area. Expand
Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae.
TLDR
The present study gives specific and useful information about antiprotozoal and cytotoxic activities of some Annonaceae extracts and demonstrates which plants and/or plant parts could be useful in the treatment of leishmaniasis, Chagas' disease and malaria. Expand
Cytotoxicity and antileishmanial activity of Annona muricata pericarp.
TLDR
Hexane, ethyl acetate and methanol extracts of Annona muricata pericarp were tested in vitro against Leishmania braziliensis and L. panamensis promastigotes, and against cell line U-937, and led to the isolation of three acetogenins. Expand
[Gender and cutaneous leishmaniasis in Colombia].
TLDR
Several factors that have not been analyzed in depth in Colombia thus far appear to distort the disease's epidemiological pattern in the country, and gender-linked differences in access to health care appear to exist. Expand
Synthesis of novel analogs of 2-pyrazoline obtained from [(7-chloroquinolin-4-yl)amino]chalcones and hydrazine as potential antitumor and antimalarial agents.
TLDR
A new series of N-acetyl and N-formyl-pyrazoline derivatives 6 and 7-8 showed remarkable antitumor activity against cancer cell lines, with the most important GI50 values ranging from 0.13 to 0.99 μM. Expand
Improvement of the green fluorescent protein reporter system in Leishmania spp. for the in vitro and in vivo screening of antileishmanial drugs.
TLDR
The platform described here for drug testing assays based on the use of stable fluorescent Leishmania strains coupled to flow cytometry and fluorescent microscopy is more sensitive, more specific and faster than conventional assays used normally for the evaluation of compounds with potential antileishmanial activity. Expand
Leishmania tarentolae: utility as an in vitro model for screening of antileishmanial agents.
TLDR
The ability of L. tarentolae to grow as axenic amastigotes is first described while its ability to infect several mammalian cells has been confirmed and offers a suitable model for the in vitro screening of compounds for antileishmanial activity. Expand
An epidemic outbreak of canine cutaneous leishmaniasis in Colombia caused by Leishmania braziliensis and Leishmania panamensis.
TLDR
The clinical features of the disease and the response to treatment with pentavalent antimonials observed in 72 guard dogs from the Colombian Army are described and a program for prevention and control of canine CL is discussed. Expand
Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies
TLDR
In vivo studies showed that the flavanone administered in solution or cream induces clinical improvement and no toxicity in hamsters with CL, and the in vitro and in vivo leishmanicidal activity reported here for 5,3′-hydroxy-7,4′-dimethoxyflavanone offers a greater prospect towards antileishmanial drug discovery and development. Expand
Safety and immunogenicity of a killed Leishmania (L.) amazonensis vaccine against cutaneous leishmaniasis in Colombia: a randomized controlled trial.
TLDR
The good safety profile and evidence of Th1 immune reactions due to i.m. vaccination in this phase-I/II study suggest that a population-based phase-III efficacy trial of the i.M. vaccine should be initiated. Expand
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