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Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
TLDR
It is concluded that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland.
Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial.
TLDR
T tandem autologous transplant resulted in a significantly better EFS than single transplant among patients aged 30 years or younger with high-risk neuroblastoma, however, because of the low randomization rate, the findings may not be representative of all patients withhigh-risk Neuroblastoma.
Immunotherapy of Childhood Sarcomas
TLDR
This review will focus on recent preclinical and clinical developments in targeted agents for pediatric sarcomas with emphasis on the immunobiology of immune checkpoints, immunoediting, tumor microenvironment, antibody engineering, cell engineering, and tumor vaccines.
Treatment and outcome of adult‐onset neuroblastoma
TLDR
Adult‐onset neuroblastoma appeared to have different biology from pediatric or adolescent NB, and poorer outcome, and complete disease control appeared to improve long‐term survival.
Lack of survival advantage with autologous stem-cell transplantation in high-risk neuroblastoma consolidated by anti-GD2 immunotherapy and isotretinoin
TLDR
A study population of two groups treated during the same period and whose consolidative therapy, aside from ASCT, was identical, found that ASCT may not be needed to improve outcome when anti-GD2 immunotherapy is used for consolidation after dose-intensive conventional chemotherapy.
COVID‐19 disease in New York City pediatric hematology and oncology patients
TLDR
A trend toward higher incidence of COVID-19 infection was observed in males, and after adjusting for institution, insurance, and ethnicity, males appeared three times more likely to have positive test results compared with females.
Integrating genomics into clinical pediatric oncology using the molecular tumor board at the Memorial Sloan Kettering Cancer Center
TLDR
The MSKCC PMTB enabled a clinically relevant interpretation of genomic profiling and developed specific rule-driven clinical protocols for the incorporation and evaluation of genomic and molecular profiling in interventional prospective clinical trials.
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