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Cannabinoids as novel anti-inflammatory drugs.
- P. Nagarkatti, Rupal Pandey, S. Rieder, V. Hegde, M. Nagarkatti
- BiologyFuture medicinal chemistry
- 21 October 2009
This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components.
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.
Coexpression of TIGIT and FCRL3 Identifies Helios+ Human Memory Regulatory T Cells
It is shown that the TIGIT/FCRL3 combination allows reliable identification of Helios+ Treg cells even in highly activated conditions in vitro as well as in PBMCs of autoimmune patients.
Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond.
Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses.
Efficient production and properties of engineered antigen-specific Tregs are reported, created by transduction of a recombinant T-cell receptor obtained from a hemophilia A subject's T- cell clone, into expanded human FoxP3(+) T Regs, suggesting potential utility to treat anti-FVIII inhibitory antibody formation in hemophili A patients.
Helios Controls a Limited Subset of Regulatory T Cell Functions
- M. Sebastian, Maria Lopez-Ocasio, A. Metidji, S. Rieder, E. Shevach, A. Thornton
- Biology, MedicineThe Journal of Immunology
- 1 January 2016
It is shown that the selective deletion of Helios in Tregs leads to slow, progressive systemic immune activation, hypergammaglobulinemia, and enhanced germinal center formation in the absence of organ-specific autoimmunity.
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination
It is shown that Bhlhe40-deficient CD4 Th1 cells produced less IFN-&ggr; but substantially more IL-10 than wild-type Th 1 cells both in vitro and in vivo, and that transcription factor Bhlle40 is a molecular switch for determining the fate of inflammatory and antiinflammatory Th1 Cells.
Multiple anti‐inflammatory pathways triggered by resveratrol lead to amelioration of staphylococcal enterotoxin B‐induced lung injury
- S. Rieder, P. Nagarkatti, M. Nagarkatti
- Biology, MedicineBritish journal of pharmacology
- 1 November 2012
The therapeutic effectiveness of resveratrol, a plant polyphenol, during SEB‐induced lung inflammation is investigated, finding it to be effective during both acute lung inflammation and respiratory failure.
CD1d-Independent Activation of Invariant Natural Killer T Cells by Staphylococcal Enterotoxin B through Major Histocompatibility Complex Class II/T Cell Receptor Interaction Results in Acute Lung…
Evidence is provided for a novel CD1d-independent direct activation of iNKT cells involving a microbial protein superantigen presented in the context of major histocompatibility complex class II (MHC-II), which plays a critical role in pathogenesis, thereby redefining the role of i NKT cells.
Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells
The studies are not consistent with a role for Eos in Treg development and function but demonstrate that Eos plays an important role in the activation and differentiation of Tconvs.