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CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.
TLDR
It is established that high CAR-T cell doses and tumor burden increase the risks of severe cytokine release syndrome and neurotoxicity, and serum biomarkers that allow testing of early intervention strategies in patients at the highest risk of toxicity are identified. Expand
Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor.
TLDR
The transfer of CMV-specific clones of CD8+ T cells derived from the bone marrow donor is a safe and effective way to reconstitute cellular immunity against CMV after allogeneic marrow transplantation. Expand
Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
TLDR
It is demonstrated that the adoptively transferred T cell clones persist in vivo in response to low-dose IL-2, preferentially localize to tumor sites and mediate an antigen-specific immune response characterized by the elimination of antigen-positive tumor cells, regression of individual metastases, and minor, mixed or stable responses in 8 of 10 patients with refractory, metastatic disease for up to 21 mo. Expand
Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells.
TLDR
A novel experimental and computational approach is developed to measure TCR CDR3 diversity based on single-molecule DNA sequencing, and it is found that total TCRbeta receptor diversity is at least 4-fold higher than previous estimates, and the diversity in the subset of CD45RO(+) antigen-experienced alphabeta T cells is at at least 10-foldHigher than previously estimates. Expand
A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.
TLDR
The molecular cloning of tapasin revealed it to be a transmembrane glycoprotein encoded by an MHC-linked gene, a member of the immunoglobulin superfamily with a probable cytoplasmic endoplasmic reticulum retention signal. Expand
The emperor of all maladies: A biography of cancer
TLDR
The Emperor of All Maladies, oncologist and research scientist Siddhartha Mukherjee makes a bold effort to chronicle the biography of cancer, which traces the nihilism and mysticism that were understandably pervasive in the earliest days of cancer therapy and highlights conceptual advances made by early physicians and pathologists. Expand
Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones.
TLDR
Cytomegalovirus-specific CD8+ cytotoxic T cell (CTL) clones could be isolated from bone marrow donors, propagated in vitro, and adoptively transferred to immunodeficient bone marrow transplant recipients and no toxicity developed and the clones provided persistent reconstitution of CD8+. Expand
Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.
TLDR
Endothelial dysfunction and increased BBB permeability in neurotoxicity are shown and it is found that patients with evidence of endothelial activation before lymphodepletion may be at increased risk of neurotoxicity. Expand
Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells.
TLDR
The results of a proof-of-concept clinical trial in which patients with relapsed or refractory indolent B-cell lymphoma or mantle cell lymphoma were treated with autologous T cells genetically modified by electroporation with a vector plasmid encoding a CD20-specific chimeric T- cell receptor and neomycin resistance gene show the safety, feasibility, and potential antitumor activity of adoptive T-cell therapy using this approach. Expand
A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes
TLDR
By expressing ICP47, HSV can evade detection by CD8+ T lymphocytes, perhaps explaining the predominance of CD4+ rather thanCD8+ HSV-specific CTLs in vivo. Expand
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