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Coordination of circadian timing in mammals
Circadian rhythms are generated by one of the most ubiquitous and well-studied timing systems and are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
Molecular analysis of mammalian circadian rhythms.
Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing.
Posttranslational Mechanisms Regulate the Mammalian Circadian Clock
Interacting molecular loops in the mammalian circadian clock.
Analysis of Clock/Clock mutant mice, homozygous Period2(Brdm1) mutants, and Cryptochrome-deficient mice reveals substantially altered Bmal1 rhythms, consistent with a dominant role of PERIOD2 in the positive regulation of the Bmal 1 loop.
Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain
mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.
- S. Reppert, C. Godson, C. D. Mahle, D. Weaver, S. Slaugenhaupt, J. Gusella
- BiologyProceedings of the National Academy of Sciences…
- 12 September 1995
The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects ofmelatonin in mammals.
Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock