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Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen-cimetidine mixtures prepared by mechanical activation.
No recrystallization of either drug in the 1:1 co-milled sample was observed during dissolution testing, with naproxen and cimetidine having a four and two times higher intrinsic dissolution rate, respectively, compared to their crystalline counterparts. Expand
Comparison of two procedures for particle-size analysis : Köhn pipette and X-ray granulometry
Knowledge on particle-size distribution (PSD) is crucial to the classification and description of soils and sediments. Since the early 1900s, various methods of PSD analysis have been in use. InExpand
Quantitative solid-state analysis of three solid forms of ranitidine hydrochloride in ternary mixtures using Raman spectroscopy and X-ray powder diffraction.
XRPD and Raman spectroscopy in combination with PLS regression can be used to quantify the amount of single components in ternary mixtures of ranitidine hydrochloride solid forms, allowing a more accurate quantification. Expand
Investigation of the Formation Process of Two Piracetam Cocrystals during Grinding
It was shown that liquid-assisted grinding led to faster cocrystal formation than dry grinding, which may be explained by the higher transformation rate due to the presence of liquid. Expand
Chemical imaging and solid state analysis at compact surfaces using UV imaging.
It is demonstrated that the multi-wavelength UV imaging is a fast process analytical technique with the potential for real-time monitoring of critical quality attributes and the critical evaluation of the mapping results and the selection of model parameters for the chemical mapping. Expand
Thermal degradation of amorphous glibenclamide.
The crystals formed during sublimation of amorphous glibenclamide do not represent a glibanclamide polymorph, but a thermal degradation product, namely 1,3-dicyclohexylurea, which may decompose to carbon monoxide and cyclohexylamine. Expand
Cassiterite fingerprinting by LA-ICP-MS
Cassiterite (SnO2) has been specified as a ‘conflict mineral’ by a U.S. Government Act. This requires all companies that use tin in their products to verify that this tin does not originate fromExpand
High-shear granulation as a manufacturing method for cocrystal granules.
It was concluded that high-shear wet granulation is a valuable, however complex, manufacturing method for cocrystals and should be investigated during pre-formulation. Expand
A case study of real-time monitoring of solid-state phase transformations in acoustically levitated particles using near infrared and Raman spectroscopy.
  • S. Rehder, J. Wu, +4 authors C. Leopold
  • Materials Science, Medicine
  • European journal of pharmaceutical sciences…
  • 23 January 2013
It was concluded that acoustic levitation with NIR and Raman spectroscopy combined with multivariate curve resolution allowed direct determination of the recrystallisation kinetics of amorphous drugs and thus is a promising technique for monitoring solid-state phase transformations of adhesive small-sized samples during the early phase of drug development. Expand