• Publications
  • Influence
Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells
TLDR
It is suggested that ectopic expression of telomerase in hMSCs prevents senescence-associated impairment of osteoblast functions. Expand
Eukaryotic protein elongation factors.
TLDR
In eukaryotes, peptide chain elongation is mediated by elongation factors EF-1 and EF-2, which are involved in functions other than protein synthesis, such as organization of the mitotic apparatus, signal transduction, developmental regulation, ageing and transformation. Expand
Theories of biological aging: Genes, proteins, and free radicals
  • S. Rattan
  • Biology, Medicine
  • Free radical research
  • 1 January 2006
TLDR
A unified theory of biological aging in terms of failure of homeodynamics comprising of MRS, and involving genes, milieu and chance, is acquiring a definitive shape and wider acceptance and establishes the basis for testing and developing effective means of intervention, prevention and modulation of aging. Expand
Number and Proliferative Capacity of Osteogenic Stem Cells Are Maintained During Aging and in Patients with Osteoporosis
TLDR
The study shows that the number and proliferative capacity of osteoprogenitor cells are maintained during aging and in patients with osteoporosis and that other mechanisms must be responsible for the defective osteoblast (OB) functions observed in these conditions. Expand
HEAT SHOCK RESPONSE AND AGEING: MECHANISMS AND APPLICATIONS
TLDR
The molecular mechanism and the state of the HS response as well as the role of specific HSPs during ageing are described, and the possibility of hormetic modulation of ageing and longevity by repeated mild stress is discussed. Expand
Kinetin inhibits protein oxidation and glycoxidation in vitro.
We tested the ability of N(6)-furfuryladenine (kinetin) to protect against oxidative and glycoxidative protein damage generated in vitro by sugars and by an iron/ascorbate system. At 50 microM,Expand
Reduced levels of oxidized and glycoxidized proteins in human fibroblasts exposed to repeated mild heat shock during serial passaging in vitro.
TLDR
Results show that the slower accumulation of damaged proteins in fibroblasts exposed to RMHS results partly from the increased ability of these cells to cope with oxidative stress, and to synthesize HSP responsible for protein capping and refolding. Expand
Rationale and methods of discovering hormetins as drugs for healthy ageing
  • S. Rattan
  • Biology, Medicine
  • Expert opinion on drug discovery
  • 28 April 2012
TLDR
The article presents the rationale and a strategy for discovering novel hormetins as potential drugs for ageing intervention by elucidating multiple stress responses of normal human cells and provides a recent example of successful product development, based on the ideas of hormesis. Expand
Increased molecular damage and heterogeneity as the basis of aging
  • S. Rattan
  • Biology, Medicine
  • Biological chemistry
  • 1 March 2008
TLDR
Mild stress-induced hormesis by physical, biological and nutritional methods, including hormetins, represents a promising strategy for achieving healthy aging and for preventing age-related diseases. Expand
N(6)-Furfuryladenine, kinetin, protects against Fenton reaction-mediated oxidative damage to DNA.
TLDR
It is demonstrated that Kinetin significantly protects the DNA against oxidative damage mediated by the Fenton reaction and inhibited 8-oxo-dG formation in a dose-dependent manner with a maximum of 50% protection observed at 100 microM kinetin. Expand
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