• Publications
  • Influence
Hormesis in aging
  • S. Rattan
  • Biology, Medicine
  • Ageing Research Reviews
  • 2008
Hormesis in aging is represented by mild stress-induced stimulation of protective mechanisms in cells and organisms resulting in biologically beneficial effects. Single or multiple exposure to lowExpand
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.
Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptiveExpand
Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress
We assessed the impact of repeated episodes of a mild heat stress on lifespan, fecundity, heat stress resistance and Hsp70 expression in Drosophila melanogaster. There was a significant increase inExpand
Synthesis, modifications, and turnover of proteins during aging
  • S. Rattan
  • Chemistry, Medicine
  • Experimental Gerontology
  • 30 April 1996
Slowing down of bulk protein synthesis is one of the most commonly observed biochemical changes during aging. The implications and consequences of slower rates of protein synthesis are manifold,Expand
Mild stress-induced stimulation of heat-shock protein synthesis and improved functional ability of human fibroblasts undergoing aging in vitro
Repeated mild heat-shock (RMHS) treatment has anti-aging hormetic effects on human fibroblasts undergoing aging in vitro. Since heat and various other stresses induce the transcription andExpand
Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention.
SCOPE Curcumin, a component of the spice turmeric, was tested for its potential hormetic anti-aging effects as an inducer of mild stress. METHODS AND RESULTS Early passage young human skinExpand
Heat Shock–Induced Enhancement of Osteoblastic Differentiation of hTERT‐Immortalized Mesenchymal Stem Cells
Abstract:  Heat shock (HS)–induced stress response in human cells results in a variety of biological effects and is known to induce the transcription of heat‐shock proteins, which help the cells toExpand
Hormesis can and Does Work in Humans
If we accept the validity of the general concept of physiological hormesis as being the phenomenon of achieving health beneficial effects by exposure to mild stress, then hormesis is being appliedExpand
Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011
  • S. Rattan
  • Biology, Medicine
  • Biogerontology
  • 1 February 2012
Ageing is a progressive shrinkage of the homeodynamic space and, at the molecular level, it is associated with the stochastic occurrence and progressive accumulation of molecular damage. ImperfectionExpand
Dicarbonyl-induced accelerated aging in vitro in human skin fibroblasts
Dicarbonyls glyoxal (GO) and methylglyoxal (MGO) produced during the autoxidation of reducing sugars are a source of macromolecular damage in cells. Since an accumulation of damaged macromolecules isExpand