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Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.
Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulatingExpand
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Leukemia Inhibitory Factor Is a Key Signal for Injury-Induced Neurogenesis in the Adult Mouse Olfactory Epithelium
The mammalian olfactory epithelium (OE) is composed of primary olfactory sensory neurons (OSNs) that are renewed throughout adulthood by local, restricted neuronal progenitor cells. The molecularExpand
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A microRNA switch regulates the rise in hypothalamic GnRH production before puberty
A sparse population of a few hundred primarily hypothalamic neurons forms the hub of a complex neuroglial network that controls reproduction in mammals by secreting the 'master molecule'Expand
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Contribution of mast cells to injury mechanisms in a mouse model of pediatric traumatic brain injury
The cognitive and behavioral deficits caused by traumatic brain injury (TBI) to the immature brain are more severe and persistent than injuries to the adult brain. Understanding this developmentalExpand
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Molecular pathways in cerebral ischemia
Stroke is one of the leading causes of death and severe disability in most industrialized countries. Despite the extensive research efforts of both academic and industrial laboratories during theExpand
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HIP/PAP prevents excitotoxic neuronal death and promotes plasticity
Excitotoxicity plays a significant role in the pathogenesis of perinatal brain injuries. Among the consequences of excessive activation of the N‐methyl‐d‐aspartate (NMDA)‐type glutamate are oxidativeExpand
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Corrigendum: A microRNA switch regulates the rise in hypothalamic GnRH production before puberty
Corrigendum: A microRNA switch regulates the rise in hypothalamic GnRH production before puberty
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Endogenous cerebellar neurogenesis in adult mice with progressive ataxia
Transplanting exogenous neuronal progenitors to replace damaged neurons in the adult brain following injury or neurodegenerative disorders and achieve functional amelioration is a realistic goal.Expand
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In Vitro Induction of Neural Differentiation of Embryonic Stem (ES) Cells Closely Mimics Molecular Mechanisms of Embryonic Brain Development
The capacity of pluripotent embryonic stem cells (ES cells) to proliferate and differentiate makes them promising tools in the field of cell therapy. In spite of the controversy surrounding theExpand
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