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An in situ brain perfusion technique to study cerebrovascular transport in the rat.
The in situ brain perfusion technique is a sensitive new method to study cerebrovascular transfer in the rat and permits absolute control of perfusate composition. Expand
Dissociation of object and spatial visual processing pathways in human extrastriate cortex.
The ventral and dorsal locations of the regions specialized for object recognition and spatial localization, respectively, suggest some homology between human and nonhuman primate extrastriate cortex, with displacement in human brain, possibly related to the evolution of phylogenetically newer cortical areas. Expand
Osmotic Opening of the Blood–Brain Barrier: Principles, Mechanism, and Therapeutic Applications
  • S. Rapoport
  • Chemistry, Medicine
  • Cellular and Molecular Neurobiology
  • 1 April 2000
In experimental animals, the osmotic method has been used to grant wide access to the brain of water-soluble drugs, peptides, antibodies, boron compounds for neutron capture therapy, and viral vectors for gene therapy. Expand
Network analysis of cortical visual pathways mapped with PET
A network analysis was performed on data obtained from a PET study that examined both the changes in regional cerebral blood flow (rCBF) and interregional correlations among human cortical areas during performance of an object vision (face matching) and spatial vision (dot- location matching) task. Expand
Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder.
A significant relationship between metabolic activity and both state and trait measurements of OCD and anxiety as well as the response to clomipramine hydrochloride therapy was found. Expand
Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism
The results demonstrate the saturable transfer of L‐KYN across the blood–brain barrier and suggest that circulating L‐ KYN, 3‐HKYN, and ANA may each contribute significantly to respective cerebral pools under normal conditions. Expand
Face encoding and recognition in the human brain.
A dissociation between human neural systems that participate in the encoding and later recognition of new memories for faces was demonstrated by measuring memory task-related changes in regional cerebral blood flow with positron emission tomography, and the most striking finding in neocortex was the lateralization of prefrontal participation. Expand
The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults
WMHI volume is associated with structural and functional brain changes even within a group of very healthy individuals and is related to elevated systolic blood pressure even when it is within the normal age-related range. Expand
Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome.
In patients presenting with cognitive symptoms of dementia, regional brain metabolism was a sensitive indicator of AD and of neurodegenerative disease in general and a negative PET scan indicated that pathologic progression of cognitive impairment during the mean 3-year follow-up was unlikely to occur. Expand
Kinetics of Neutral Amino Acid Transport Across the Blood‐Brain Barrier
Predicted influx values from transport constants and average plasma concentrations agree well with values measured using plasma perfusate and suggest that affinity of a l‐α‐amino acid for the transport system is determined primarily by side‐chain hydrophobicity. Expand