Dissociation of object and spatial visual processing pathways in human extrastriate cortex.
- J. Haxby, C. Grady, S. Rapoport
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 1 March 1991
The ventral and dorsal locations of the regions specialized for object recognition and spatial localization, respectively, suggest some homology between human and nonhuman primate extrastriate cortex, with displacement in human brain, possibly related to the evolution of phylogenetically newer cortical areas.
An in situ brain perfusion technique to study cerebrovascular transport in the rat.
The in situ brain perfusion technique is a sensitive new method to study cerebrovascular transfer in the rat and permits absolute control of perfusate composition.
Network analysis of cortical visual pathways mapped with PET
- A. McIntosh, C. Grady, Leslie G. Ungerleider, J. Haxby, S. Rapoport, B. Horwitz
- PsychologyJournal of Neuroscience
- 1 February 1994
A network analysis was performed on data obtained from a PET study that examined both the changes in regional cerebral blood flow (rCBF) and interregional correlations among human cortical areas during performance of an object vision (face matching) and spatial vision (dot- location matching) task.
Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism
- S. Fukui, R. Schwarcz, S. Rapoport, Y. Takada, Q. Smith
- Biology, ChemistryJournal of Neurochemistry
- 1 June 1991
The results demonstrate the saturable transfer of L‐KYN across the blood–brain barrier and suggest that circulating L‐ KYN, 3‐HKYN, and ANA may each contribute significantly to respective cerebral pools under normal conditions.
Face encoding and recognition in the human brain.
- J. Haxby, Leslie G. Ungerleider, B. Horwitz, J. Maisog, S. Rapoport, C. Grady
- Psychology, BiologyProceedings of the National Academy of Sciences…
- 23 January 1996
A dissociation between human neural systems that participate in the encoding and later recognition of new memories for faces was demonstrated by measuring memory task-related changes in regional cerebral blood flow with positron emission tomography, and the most striking finding in neocortex was the lateralization of prefrontal participation.
Osmotic Opening of the Blood–Brain Barrier: Principles, Mechanism, and Therapeutic Applications
- S. Rapoport
- Biology, MedicineCellular and Molecular Neurobiology
- 1 April 2000
In experimental animals, the osmotic method has been used to grant wide access to the brain of water-soluble drugs, peptides, antibodies, boron compounds for neutron capture therapy, and viral vectors for gene therapy.
Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder.
A significant relationship between metabolic activity and both state and trait measurements of OCD and anxiety as well as the response to clomipramine hydrochloride therapy was found.
Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome.
In patients presenting with cognitive symptoms of dementia, regional brain metabolism was a sensitive indicator of AD and of neurodegenerative disease in general and a negative PET scan indicated that pathologic progression of cognitive impairment during the mean 3-year follow-up was unlikely to occur.
The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults
WMHI volume is associated with structural and functional brain changes even within a group of very healthy individuals and is related to elevated systolic blood pressure even when it is within the normal age-related range.
Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging.
Significant sex differences in aging of brain areas that are essential to higher cognitive functioning are found and may explain some of the age-sex differences in human cognition and response to brain injury and disease.