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Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.
  • B. Osterud, S. Rapaport
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 December 1977
A study was carried out on mechanisms, independent of activated Factor XI, capable of activating Factor IX. The reaction product of tissue factor and Factor VII functioned as a potent Factor IXExpand
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Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody.
Tissue factor, the cofactor for factor VIIa-catalyzed activation of factors IX and X, plays an important role in the initiation of hemostasis. However, the distribution of tissue factor in the bodyExpand
  • 394
  • 8
The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies.
The partial thromboplastin time (PPT) test consists of recalcifying plasma in the presence of a lipid reagent that supplies optimal platelet thromboplastic factor-like activity. Thus, the testExpand
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Acquired inhibitors of blood coagulation.
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Initiation and regulation of tissue factor-dependent blood coagulation.
  • 287
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Disseminated intravascular coagulation in rabbits induced by administration of endotoxin or tissue factor: effect of anti-tissue factor antibodies and measurement of plasma extrinsic pathway
Rabbits were given polyclonal anti-tissue factor (TF) immunoglobulin G (IgG) before an injection of endotoxin to test the hypothesis that TF triggers disseminated intravascular coagulation (DIC)Expand
  • 191
  • 5
  • PDF
Defibrination after brain-tissue destruction: A serious complication of head injury.
Abstract A prospective study was conducted to evaluate defibrination after acute head trauma. Defibrination was not observed in 13 patients In whom trauma apparently did not destroy brain tissue. InExpand
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The basalis of the primate endometrium: a bifunctional germinal compartment.
Radioautographic analysis of epithelial and stromal cell proliferation in the primate endometrial functionalis and basalis (rhesus monkey) has identified horizontal zonal patterns of mitoticExpand
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Correction of Excessive Anticoagulation with Low-Dose Oral Vitamin K1
Excessive anticoagulation with an international normalized ratio (INR) that exceeds 5.0 (a value > 5.0 increases the risk for hemorrhage) is common in patients who are receiving warfarin therapyExpand
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