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NFAT5 Regulates HIV-1 in Primary Monocytes via a Highly Conserved Long Terminal Repeat Site
A novel host factor–viral enhancer interaction that reveals a new regulatory role for NFAT5 is defined and a functional DNA motif conserved across HIV-1 subtypes and representative simian immunodeficiency viruses is defined. Expand
HIV-1 Replication Is Differentially Regulated by Distinct Clinical Strains of Mycobacterium tuberculosis
It is shown that HIV-1 co-infection with the CDC1551 MTb strain results in higher levels of virus replication relative to co- infecting with the HN878MTb strain ex vivo. Expand
Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.
Although 1 or 2 mutations at peripheral sites are tolerated, mutations in the central target cleavage region abolish RNAi activity, which is a major hurdle for potential therapeutic use of RNA interference (RNAi) against HIV-1. Expand
Mycobacterium tuberculosis Recall Antigens Suppress HIV-1 Replication in Anergic Donor Cells via CD8+ T Cell Expansion and Increased IL-10 Levels1
Immunotherapeutic approaches aimed at recapitulating Ag-specific MTb anergy in vivo could result in novel and effective approaches to inhibit HIV-1 disease progression in MTb/HIV-1 coinfection. Expand
Standard conditions of virus isolation reveal biological variability of HIV type 1 in different regions of the world. WHO Network for HIV Isolation and Characterization.
Using syncytium induction as a marker, changes in virus populations during early in vitro passage in PBMC could be observed, and all viruses from Brazil, Rwanda, and Thailand showed a slow/low replicative pattern. Expand
The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus
NTZ counteracts varied virus-specific immune evasion strategies by generally enhancing the RNA sensing and interferon axis that is triggered by foreign cytoplasmic RNA exposure, and holds promise as an oral therapy against EBOV. Expand
TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice.
In models of human sexual transmission, a localized interferon response inhibits HIV transmission but systemic interferons do not, and intravaginal application of type Iinterferons the day before HIV infection induced interferOn responsive genes, reduced inflammation, and decreased viral replication, however, intravenous interfer on enhanced inflammation and infection. Expand
Regulation of Mycobacterium tuberculosis-Dependent HIV-1 Transcription Reveals a New Role for NFAT5 in the Toll-Like Receptor Pathway
Tuberculosis (TB) disease in HIV co-infected patients contributes to increased mortality by activating innate and adaptive immune signaling cascades that stimulate HIV-1 replication, leading to anExpand
A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection
Findings provide evidence that the antiviral IFITMs participate in the restriction of mycobacterial growth, and they implicate IFITM-mediated endosomal maturation in its antimycob bacterial activity. Expand
Transactivator of Transcription from HIV Type 1 Subtype E Selectively Inhibits TNF Gene Expression via Interference with Chromatin Remodeling of the TNF Locus1
It is demonstrated that Tat proteins from representative HIV-1 subtype E isolates, but not from subtypes B or C, selectively inhibit TNF gene transcription and protein production in CD4+ Jurkat T cells, and this repression is due to a tryptophan at residue 32 of Tat E. Expand