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Signaling and transcription in T helper development.
The recognition of polarized T cell subsets defined by cytokine production was followed by a search to define the factors controlling this phenomenon. Suitable in vitro systems allowed theExpand
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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in
Soluble guanylate cyclase (sGC), a key signal-transduction enzyme, increases the conversion of guanosine-5′-triphosphate to cGMP upon binding of nitric oxide (NO). Endothelial dysfunction and/orExpand
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Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo
Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6 is a hallmark of immune-mediatedExpand
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IWP-121: a novel sGC stimulator that reduces blood pressure and exhibits anti-fibrotic and anti-inflammatory activities in the Dahl Salt-Sensitive rat model
Background Soluble guanylate cyclase (sGC) is an intracellular receptor that can be activated by nitric oxide (NO) and sGC stimulators to produce cyclic guanosine monophosphate (cGMP), therebyExpand
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V b cluster sequences reduce the frequency of primary V b 2 and V b 14 rearrangements
1 Department of Pathology and Laboratory Medicine, Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Abramson Family Cancer Research Institute, University of PennsylvaniaExpand
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sGC Stimulator Efficacy Beyond Blood Pressure in Dahl-Salt Sensitive Model of Hypertension
Soluble guanylate cyclase (sGC) is an important intracellular receptor that can be activated by sGC stimulators to produce cyclic guanosine monophosphate (cGMP)protein kinase G (PKG) mediated effec...
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H2ax/p53-deficient thymic lymphomas with clonal translocations Aberrant V(D)J recombination is not required for rapid development of
http://bloodjournal.hematologylibrary.org/cgi/content/full/111/4/2163 Updated information and services can be found at: (3952 articles) Neoplasia • (3443 articles) Immunobiology • collections:Expand
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Abstract 4871: Two novel anti-PD-1 antibodies, 244C8 and 388D4, elicitin vivoantitumor efficacy in a lung PDX tumorgraft in immuno-humanized NSG mice
We have previously described the identification of more than 300 anti-PD-1 monoclonal antibody candidates using Enumeral9s proprietary single cell immune-profiling technology, on which our antibodyExpand
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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors
Hematopoietic progenitor kinase 1 (HPK1), also referred to as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1), is a serine/threonine kinase that negatively regulates T-cell signalingExpand
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ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells.
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that accumulate in the tumor microenvironment (TME). MDSCs have been shown to dampen anti-tumor immune responses and promote tumorExpand