S. Ranganath

Publications13
h-index3
Citations721
Highly Influential Citations31
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Signaling and transcription in T helper development.
The recognition of polarized T cell subsets defined by cytokine production was followed by a search to define the factors controlling this phenomenon. Suitable in vitro systems allowed the… Expand
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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in…
Soluble guanylate cyclase (sGC), a key signal-transduction enzyme, increases the conversion of guanosine-5′-triphosphate to cGMP upon binding of nitric oxide (NO). Endothelial dysfunction and/or… Expand
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Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo
Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6 is a hallmark of immune-mediated… Expand
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IWP-121: a novel sGC stimulator that reduces blood pressure and exhibits anti-fibrotic and anti-inflammatory activities in the Dahl Salt-Sensitive rat model
Background Soluble guanylate cyclase (sGC) is an intracellular receptor that can be activated by nitric oxide (NO) and sGC stimulators to produce cyclic guanosine monophosphate (cGMP), thereby… Expand
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V b cluster sequences reduce the frequency of primary V b 2 and V b 14 rearrangements
1 Department of Pathology and Laboratory Medicine, Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Abramson Family Cancer Research Institute, University of Pennsylvania… Expand
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sGC Stimulator Efficacy Beyond Blood Pressure in Dahl-Salt Sensitive Model of Hypertension
Soluble guanylate cyclase (sGC) is an important intracellular receptor that can be activated by sGC stimulators to produce cyclic guanosine monophosphate (cGMP)protein kinase G (PKG) mediated effec...
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H2ax/p53-deficient thymic lymphomas with clonal translocations Aberrant V(D)J recombination is not required for rapid development of
http://bloodjournal.hematologylibrary.org/cgi/content/full/111/4/2163 Updated information and services can be found at: (3952 articles) Neoplasia • (3443 articles) Immunobiology • collections:… Expand
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Abstract 4871: Two novel anti-PD-1 antibodies, 244C8 and 388D4, elicitin vivoantitumor efficacy in a lung PDX tumorgraft in immuno-humanized NSG mice
We have previously described the identification of more than 300 anti-PD-1 monoclonal antibody candidates using Enumeral9s proprietary single cell immune-profiling technology, on which our antibody… Expand
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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors
Hematopoietic progenitor kinase 1 (HPK1), also referred to as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1), is a serine/threonine kinase that negatively regulates T-cell signaling… Expand
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ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells.
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that accumulate in the tumor microenvironment (TME). MDSCs have been shown to dampen anti-tumor immune responses and promote tumor… Expand