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Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
BackgroundThe Janus kinase (JAK) family of tyrosine kinases includes JAK1, JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II cytokine receptors. CP-690,550 is a potent andExpand
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Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.
Betulinic acid is a pentacyclic triterpene natural product initially identified as a melanoma-specific cytotoxic agent that exhibits low toxicity in animal models. Subsequent studies show thatExpand
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A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters.
  • S. Ramaiah
  • Biology, Medicine
  • Food and chemical toxicology : an international…
  • 1 September 2007
Assessing liver damage in basic toxicology research and in preclinical toxicity testing is usually evaluated by serum biochemical parameters prior to confirmation by histopathology. With the adventExpand
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Role of Neutrophils in the Pathogenesis of Acute Inflammatory Liver Injury
Polymorphonuclear leukocytes (neutrophils) are essential in the defense against invading microorganisms, tissue trauma or any inciting inflammatory signals. Hepatic infiltration of neutrophils is anExpand
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Mechanisms of immune-mediated liver injury.
Hepatic inflammation is a common finding during a variety of liver diseases including drug-induced liver toxicity. The inflammatory phenotype can be attributed to the innate immune response generatedExpand
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Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways.
Nerve growth factor-induced Balpha (NGFI-Balpha, Nur77) is an orphan nuclear receptor with no known endogenous ligands; however, recent studies on a series of methylene-substituted diindolylmethanesExpand
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Activation of Nur77 by Selected 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes Induces Apoptosis through Nuclear Pathways*
Nur77 is an orphan receptor and a member of the nerve growth factor-I-B subfamily of the nuclear receptor family of transcription factors. Based on the results of transactivation assays in pancreaticExpand
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Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury.
Drug-induced liver injury (DILI) is the most frequent cause of discontinuation of new chemical entities during development. DILI can either be intrinsic/predictable or an idiosyncratic type. TheseExpand
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Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer.
Osteopontin (OPN) is a highly modified integrin-binding extracellular matrix glycophosphoprotein produced by cells of the immune system, epithelial tissue, smooth muscle cells, osteoblasts, and tumorExpand
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Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitis.
Alcoholic liver disease (ALD) is a major complication of heavy alcohol (EtOH) drinking and is characterized by three progressive stages of pathology: steatosis, steatohepatitis, andExpand
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