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Temporal Variations in the Hepatitis C Virus Intrahost Population during Chronic Infection
ABSTRACT The intrahost evolution of hepatitis C virus (HCV) holds keys to understanding mechanisms responsible for the establishment of chronic infections and to development of a vaccine andExpand
Hepatitis A Virus Outbreaks Associated with Drug Use and Homelessness — California, Kentucky, Michigan, and Utah, 2017
During 2017, CDC received 1,521 reports of acute hepatitis A virus (HAV) infections from California, Kentucky, Michigan, and Utah; the majority of infections were among persons reporting injection orExpand
Epidemic History and Evolutionary Dynamics of Hepatitis B Virus Infection in Two Remote Communities in Rural Nigeria
Background In Nigeria, hepatitis B virus (HBV) infection has reached hyperendemic levels and its nature and origin have been described as a puzzle. In this study, we investigated the molecularExpand
End-point limiting-dilution real-time PCR assay for evaluation of hepatitis C virus quasispecies in serum: performance under optimal and suboptimal conditions.
An approach for determination of hepatitis C virus (HCV) quasispecies by end-point limiting-dilution real-time PCR (EPLD-PCR) is described. It involves isolation of individual coexisting sequenceExpand
Convergence and coevolution of Hepatitis B virus drug resistance
Treatment with lamivudine of patients infected with hepatitis B virus (HBV) results in a high rate of drug resistance, which is primarily associated with the rtM204I/V substitution in the HBV reverseExpand
Accurate Genetic Detection of Hepatitis C Virus Transmissions in Outbreak Settings.
Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks of hepatitis C virus (HCV) infections are associated with unsafe injection practices, drug diversion, andExpand
Recent Population Expansions of Hepatitis B Virus in the United States
ABSTRACT The recent epidemic history of hepatitis B virus (HBV) infections in the United States is complex, as indicated by current disparity in HBV genotype distribution between acute and chronicExpand
QUENTIN: reconstruction of disease transmissions from viral quasispecies genomic data
We propose QUasispecies Evolution, Network-based Transmission INference (QUENTIN), a computational framework for inference of transmission history from viral genomic data that considers intra-host diversity of pathogens. Expand
Hepatitis C Virus Antigenic Convergence
Vaccine development against hepatitis C virus (HCV) is hindered by poor understanding of factors defining cross-immunoreactivity among heterogeneous epitopes. Using synthetic peptides and mouseExpand
Detection of hepatitis C virus transmission by use of DNA mass spectrometry.
The molecular detection of transmission of rapidly mutating pathogens such as hepatitis C virus (HCV) is commonly achieved by assessing the genetic relatedness of strains among infected patients. WeExpand