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Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth.
The authors have established a long-term tissue culture cell line (BON) derived from a metastatic human carcinoid tumor of the pancreas. The cells have been in continuous passage for 46 months.Expand
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Characterization of a Human Pancreatic Carcinoid in Vitro: Morphology, Amine and Peptide Storage, and Secretion
The study of functioning human endocrine tumors has been hampered by a lack of suitable in vitro models. We have established the first permanent cell line of a human pancreatic carcinoid tumor (BON)Expand
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Selective inhibition of NF-kappaB attenuates the severity of cerulein-induced acute pancreatitis.
BACKGROUND Acute pancreatitis (AP) is associated with increased cytokine production, which can ultimately produce deleterious local and systemic effects. The transcription factor NF-kappaB isExpand
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Prevalence of HIV-associated nephropathy in autopsies of HIV-infected patients.
Previous studies have reported that approximately 10% of the patients with human immunodeficiency virus (HIV) infection develop HIV-associated nephropathy (HIVAN). However, over the last decade,Expand
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Is the Prevalence of HIV-Associated Nephropathy Decreasing?
Initial reports have suggested that approximately 10% of patients with HIV-infection develop HIV-associated nephropathy (HIVAN). It has also been predicted that by the end of the decade, HIVAN isExpand
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Glutamine deprivation induces apoptosis in intestinal epithelial cells.
BACKGROUND Glutamine is the most abundant amino acid in the blood, and its deprivation leads to gut mucosal atrophy. The small intestinal mucosa is maintained by a balance between cell proliferationExpand
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Differential expression of the neurotensin gene in the developing rat and human gastrointestinal tract.
Neurotensin (NT) is an important hormone regulating gut motility, secretion, and growth. The purpose of this study was to determine the developmental expression of the NT/neuromedin N gene (NT/N) inExpand
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Intestinal peptide YY: ontogeny of gene expression in rat bowel and trophic actions on rat and mouse bowel.
The purpose of this study was twofold: 1) to characterize the profile of colonic peptide YY (PYY) gene expression in rats and 2) to examine for potential trophic effects of PYY on the intestine inExpand
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Expression of MDR1 (multidrug resistance) gene and its protein in normal human kidney.
P-glycoprotein (Pgp), the product of the multidrug resistance (MDR) gene overexpressed in cancer cells, is present also in normal tissues. In the kidney, MDR1 Pgp has been found in the proximalExpand
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Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury.
BACKGROUND & AIMS Cyclooxygenase (COX) catalyzes the rate-limiting step in prostaglandin production; the inducible isoform, COX-2, has been implicated in a variety of inflammatory processes. The roleExpand
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