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EBF2 determines and maintains brown adipocyte identity.
The master transcription factor Pparγ regulates the general differentiation program of both brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat lineage-specific… Expand
Ebf2 is a selective marker of brown and beige adipogenic precursor cells
- Wenshan Wang, Megan Kissig, +4 authors P. Seale
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2 September 2014
Significance High levels of brown/beige fat activity protects animals against metabolic disease, but there has been little known about the precursor cells that mediate the expansion of brown or beige… Expand
PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.
PR (PRD1-BF1-RIZ1 homologous) domain-containing 16 (PRDM16) drives a brown fat differentiation program, but the mechanisms by which PRDM16 activates brown fat-selective genes have been unclear.… Expand
An Evi1-C/EBPβ Complex Controls Peroxisome Proliferator-Activated Receptor γ2 Gene Expression To Initiate White Fat Cell Differentiation
- Jeff Ishibashi, Zeynep Firtina, +4 authors P. Seale
- Biology, Medicine
- Molecular and Cellular Biology
- 2 April 2012
ABSTRACT Fibroblastic preadipocyte cells are recruited to differentiate into new adipocytes during the formation and hyperplastic growth of white adipose tissue. Peroxisome proliferator-activated… Expand
Transcriptional control of brown adipocyte development
AN EFFICIENT INFORMATION RETRIEVAL FROM DOMAIN EXPERT USING ACTIVE LEARNING WITH GENERALIZED QUERIES
In recent years, domain-driven data mining (D3M) has received extensive attention in data mining. Unlike the traditional data-driven data mining, D3M tends to discover actionable knowledge by tightly… Expand
Molecular regulation of brown and beige fat cell fate