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Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system
Although many bacterial pathogens use specialized secretion systems for virulence, no such systems have been described for Mycobacterium tuberculosis, a major pathogen of humans that proliferates inExpand
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Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen
How the innate immune system tailors specific responses to diverse microbial infections is not well understood. Cells use a limited number of host receptors and signaling pathways to bothExpand
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A non‐RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis
The Snm secretion system is a crucial virulence determinant of Mycobacterium tuberculosis. Genes encoding all known components of this alternative secretion pathway are clustered at the same geneticExpand
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ESX‐1‐dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection
Exocytosis of lysosomes from macrophages has been described as a response to microbial cytotoxins and haemolysins, as well as for releasing pro‐inflammatory cytokines interleukin (IL)‐1β and IL‐18Expand
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Secreted transcription factor controls Mycobacterium tuberculosis virulence
Bacterial pathogens trigger specialized virulence factor secretion systems on encountering host cells. The ESX-1 protein secretion system of Mycobacterium tuberculosis—the causative agent of theExpand
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Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564Expand
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Incident Type 2 Diabetes Risk is Influenced by Obesity and Diabetes in Social Contacts: a Social Network Analysis
ABSTRACTBACKGROUNDObesity and diabetes family history are the two strongest risk factors for type 2 diabetes (T2D). Prior work shows that an individual’s obesity risk is associated with obesity inExpand
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Characteristics Associated With Decreased or Increased Mortality Risk From Glycemic Therapy Among Patients With Type 2 Diabetes and High Cardiovascular Risk: Machine Learning Analysis of the ACCORD
OBJECTIVE Identifying patients who may experience decreased or increased mortality risk from intensive glycemic therapy for type 2 diabetes remains an important clinical challenge. We sought toExpand
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Coronary artery disease severity modifies associations between glycemic control and both mortality and myocardial infarction.
AIMS This study examined whether the association between hemoglobin A1c (HbA1c) and short-term clinical outcomes is moderated by CAD severity. METHODS We studied 17,394 US Veterans with type 2Expand
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Transcriptional modulation of mouse mu-opioid receptor distal promoter activity by Sox18.
Previously, we reported the presence of dual promoters, referred to as distal (DP) and proximal, with a negative regulatory element between them in the mouse mu-opioid receptor (mor) gene. Here weExpand
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