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Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors.
TLDR
In an in vivo human model, it is found that the neo-intima formed on the surface of left ventricular assist devices is colonized with AC133(+)VEGFR-2(+) cells, suggesting a phenotypically and functionally distinct population of circulating endothelial cells that may play a role in neo-angiogenesis. Expand
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
TLDR
A requirement for VEGFR1+ haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) home to tumour-specific pre-metastatic sites and form cellular clusters before the arrival of tumour cells is demonstrated. Expand
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
TLDR
It is demonstrated that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells. Expand
Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand
Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals. Matrix metalloproteinase-9 (MMP-9),Expand
Evidence for circulating bone marrow-derived endothelial cells.
TLDR
It is demonstrated that a subset of CD34(+) cells have the capacity to differentiate into endothelial cells in vitro in the presence of basic fibroblast growth factor, insulin-like growth factor-1, and vascular endothelial growth factor. Expand
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
TLDR
It is demonstrated that recruitment of VEGF-responsive BM-derived precursors is necessary and sufficient for tumor angiogenesis and suggested new clinical strategies to block tumor growth are suggested. Expand
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.
TLDR
The data suggest that CD133 expression is not restricted to intestinal stem or cancer-initiating cells, and during the metastatic transition, CD133+ tumor cells might give rise to the more aggressive CD133(- )subset, which is also capable of tumor initiation in NOD/SCID mice. Expand
Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets.
TLDR
It is concluded that human megakaryocytes produce and secrete VEGF in an inducible manner and may contribute to the proliferation of endothelial cells within the bone marrow microenvironment. Expand
Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis
TLDR
Microvascular damage regulates tumor cell response to radiation at the clinically relevant dose range, indicating that endothelial apoptosis is a homeostatic factor regulating angiogenesis-dependent tumor growth. Expand
Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells
Tyrosine kinase receptors for angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) are expressed not only by endothelial cells but also by subsets of hematopoieticExpand
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