S. R. Alluri

Publications7
h-index3
Citations22
Highly Influential Citations0
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Poly(ADP-ribose) Polymerase in Neurodegeneration: Radiosynthesis and Radioligand Binding in ARC-SWE tg Mice.
TLDR
The synthesis, radiosynthesis, and characterization of a radioligand for poly(ADP-ribose) polymerase (PARP) is reported and the binding of [3H]rucaparib was found to be confined to PARP-expressing domains, for example, cerebellar cortex or hippocampal regions in both models.
Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography.
TLDR
A variety of substituted non-racemic aziridine-2-carboxylates equivalent to amino acids were prepared and subjected to ring opening reaction by [18F/19F]fluoride, finding the applicability of the methods to afford access to 3-fluoro amino acids is illustrated.
Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts
TLDR
The influx rate of 18F-FASu reflects xCT activity in tumour xenografts, and shows higher SUVE, whilst 18f-FDG exhibited higher SUVL.
PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives
TLDR
An overview of the development of positron emission tomography radiotracers for in vivo imaging of AR system in the brain and the lack of subtype specific ligands for ARs and brain penetrability issues is provided.
Synthesis, radiosynthesis and positron emission tomography neuroimaging using 5-[18 F]fluoro-L-amino suberate.
TLDR
The synthesis procedures of tosylate precursor and its translation to Sxc - PET tracer 5[18F]fluoro-L-amino suberate by manual and automated radiosyntheses are described and a brain-PET study has been conducted to evaluate the tracer uptake into brain in healthy mice.
PET Imaging Radiotracers of Chemokine Receptors
TLDR
Recent advances in the development of radiotracers for various chemokine receptors, particularly of CXCR4, CCR2, and CCR5, shed new light onChemokine-related cancer and cardiovascular research and the subsequent drug development are presented.
Development of a small-molecule CXCR3 PET radiotracer for atherosclerosis imaging in live animals