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Intranasal delivery: physicochemical and therapeutic aspects.
The relationship between thermodynamics and the toxicity of gadolinium complexes.
Preclinical evaluation of MnDPDP: new paramagnetic hepatobiliary contrast agent for MR imaging.
Results of the authors' acute and subchronic toxicity studies suggest that MnD PDP will be safe at the doses necessary for clinical imaging; at 10 mumol/kg, the safety factor for MnDPDP is significantly greater than the safety factors of Gd-DTPA (ie, 60-100).
Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel
QW8184, a stable sub-micron o/w emulsion of paclitaxel has been developed that can be filter-sterilized and administered i.v. as a bolus dose and exhibited reduced toxicity and improved efficacy most likely due to the composition and dependent physicochemical characteristics of the emulsion.
Therapeutic utility of a novel tight junction modulating peptide for enhancing intranasal drug delivery.
The TJM peptide was as or more effective in enhancing PYY(3-36) permeation in vivo at a 1000-fold lower molar concentration compared to using LMW enhancers.
Tumor shedding and coagulation.
Three syngeneic carcinomas from two species shed plasma membrane vesicles when cultured in vitro or grown in the ascites tumor form in vivo. Shed vesicles carry procoagulant activity that can account…
Conformational studies of aqueous melittin: thermodynamic parameters of the monomer-tetramer self-association reaction.
The self-association reaction in which four melittin molecules associate to form an aqueously soluble tetramer was studied by fluorescent spectroscopy and the ionic strength dependence of the tetramerization reaction was found to be consistent with an Edsall-Wyman treatment of activity coefficients.
Hepatobiliary MR imaging: first human experience with MnDPDP.
The first human MR imaging results for the hepatobiliary contrast agent manganese(II)N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (MnDPDP) are reported. MnDPDP is a paramagnetic…
Identification of tight junction modulating lipids.
- Shu-Chih Chen-Quay, Kristine T Eiting, Ang Li, N. Lamharzi, S. Quay
- BiologyJournal of pharmaceutical sciences
- 1 February 2009
It is demonstrated that three new classes of lipids, excluding alkylglycosides, show potential utility for transmucosal drug delivery.