• Publications
  • Influence
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
In Alzheimer's disease brains, more than 90% of pyramidal neurons in lamina V and 70% in lamina III displayed 2- to 5-fold elevated levels of cathepsin D (Cat D) mRNA by in situ hybridizationExpand
  • 336
  • 4
Identification of an ionic strength sensitive nuclear protein kinase activity from the cervical carcinoma HeLa.
  • S. Quarless
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 31 December 1985
A cyclic nucleotide independent, serine-threonine protein kinase activity has been purified approximately 700 fold from the nuclei of HeLa cells. This activity has a very strict ionic strengthExpand
  • 5
Regulation of nerve growth factor gene expression in primary brain monolayer cultures: effects of dibutyryl cyclic AMP and sodium butyrate.
Primary brain cultures composed of a heterogeneous population of cells, most of which reacted with anti-fibronectin and only few with anti-GFAP antiserum, were found to synthesize a mRNAExpand
  • 8
Analysis of RNA structure by ultraviolet crosslinking and denaturation gel electrophoresis.
Electrophoresis in polyacrylamide gels containing both formamide and urea is a high-resolution technique for the analysis of crosslinked RNA species. Combined with a specific crosslinking agent likeExpand
  • 5
Coupled endo-exodeoxyribonuclease activity from HeLa cell nuclei can function in an excision repair mode in vitro.
  • S. Quarless
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 31 January 1985
A single strand specific coupled endo-exodeoxyribonuclease activity has been purified and characterized from the nuclei of HeLa cells(7). The novelity of this activity is in the nature of itsExpand
Identification of a deoxyribonuclease activity in the nuclei of the cervical carcinoma HeLa.
A deoxyribonuclease activity has been identified in the nuclei of the human cervical carcinoma HeLa. This activity has the novel property of existing as a single strand specific endo- andExpand
Coupled endo-exodeoxyribonuclease activity from HeLa cell nuclei interacts with specific regions of the SV40 mini chromosome.
  • S. Quarless
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 31 January 1985
A recently described endo-exodeoxyribonuclease activity (1) was determined to interact preferentially with the origin/enhancer region and the 5' end of the late promoter region of the SV40 miniExpand