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Monolithic microfabricated valves and pumps by multilayer soft lithography.
An extension to the soft lithography paradigm, multilayersoft lithography, with which devices consisting of multiple layers may be fabricated from soft materials is described, to build active microfluidic systems containing on-off valves, switching valves, and pumps entirely out of elastomer.
Association of reactive oxygen species levels and radioresistance in cancer stem cells
It is shown that normal mammary epithelial stem cells contain lower concentrations of ROS than their more mature progeny cells, and subsets of CSCs in some tumours contain lower ROS levels and enhanced ROS defences compared to their non-tumorigenic progeny, which may contribute to tumour radioresistance.
Microfluidics: Fluid physics at the nanoliter scale
Microfabricated integrated circuits revolutionized computation by vastly reducing the space, labor, and time required for calculations. Microfluidic systems hold similar promise for the large-scale…
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
A survey of human brain transcriptome diversity at the single cell level
The first, to the authors' knowledge, single cell whole transcriptome analysis of human adult cortical samples is described, establishing an experimental and analytical framework with which the complexity of the human brain can be dissected on the single cell level.
Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq
The results confirmed the basic outlines of the classical model of epithelial cell-type diversity in the distal lung and led to the discovery of many previously unknown cell- type markers, including transcriptional regulators that discriminate between the different populations.
Dynamic pattern formation in a vesicle-generating microfluidic device.
It is shown that a microfluidic device designed to produce reverse micelles can generate complex, ordered patterns as it is continuously operated far from thermodynamic equilibrium.
A Systems Approach to Measuring the Binding Energy Landscapes of Transcription Factors
With this platform, a high-throughput microfluidic platform is described that characterized DNA binding energy landscapes for four eukaryotic transcription factors and was used to test basic assumptions about transcription factor binding and to predict their in vivo function.
Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
This model in which AML develops by serial acquisition of mutations in long-lived self-renewing hematopoietic stem cells (HSCs) suggest the clonal evolution of AML genomes from founder mutations, revealing a potential mechanism contributing to relapse.
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
A compendium of single-cell transcriptomic data from the model organism Mus musculus that comprises more than 100,000 cells from 20 organs and tissues is presented, representing a new resource for cell biology and enabling the direct and controlled comparison of gene expression in cell types that are shared between tissues.