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β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs
Modulation of Munc13-1 activity by second messengers via the DAG/beta phorbol ester binding C(1) domain is essential for use-dependent alterations of synaptic efficacy and survival. Expand
The effects of temperature on vesicular supply and release in autaptic cultures of rat and mouse hippocampal neurons
The findings indicate that the dynamics of vesicular supply and release in hippocampal neurons at room temperature are significantly different at near physiological temperatures and could affect the present understanding of the way in which individual neurons and networks of neurons process information. Expand
VMAT-Mediated Changes in Quantal Size and Vesicular Volume
Results indicate that when quantal size is altered via the vesicular monoamine transporter the concentration of catecholamines within the vESicles remains relatively constant, providing new insight into how catecholinamines can be packaged in and released from secretory vesicles. Expand
Extrasynaptic Localization of Inactivating Calcium-Activated Potassium Channels in Mouse Inner Hair Cells
Auditory hair cells from nonmammalian vertebrates are electrically tuned to specific sound frequencies primarily by the interactions of voltage-gated calcium channels and calcium-activated potassiumExpand
Distribution of the Na,K-ATPase α Subunit in the Rat Spiral Ganglion and Organ of Corti
Findings suggest that both the NKA α1 and NKAα3 are poised to play an essential role in the regulation of the type I afferent synapses, the medial efferentsynapses, and also glutamate transport from the afferent-inner hair cell synapse. Expand
Glutamatergic Signaling at the Vestibular Hair Cell Calyx Synapse
It is proposed that similar to other brain areas, such as the cerebellum and hippocampus, glutamate spillover may play a role in gain control of calyx afferents and contribute to their high-pass properties. Expand
Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea.
Measurements of cochlear frequency, the magnitude of BK and SK2 expression in outer hair cells and the strength of in vivo OC suppression in BK(+/+) mice vs. BK(-/-) lacking the obligatory α-subunit show evidence for both SK2 and BK contributions to OC effects evoked by electrically stimulating the OC bundle. Expand
BK Channels Mediate Cholinergic Inhibition of High Frequency Cochlear Hair Cells
The findings suggest that basal (high frequency) outer hair cells may employ an alternative mechanism of efferent inhibition mediated by BK channels instead of SK2 channels, which may be related to the unique acetylcholine receptors that have evolved in mammalian hair cells compared to those of other vertebrates. Expand
Circadian Clock Gene Expression in the Coral Favia fragum over Diel and Lunar Reproductive Cycles
The results suggest a molecular clock mechanism, potentially similar to that in described in fruit flies, exists within F. fragum. Expand
Cochlear Function in Mice Lacking the BK Channel α, β1, or β4 Subunits*
Findings reveal the fundamentally different contribution of BK channels to nonmammalian and mammalian hearing and suggest that BK channel should be considered a target in the prevention of noise-induced hearing loss. Expand