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In vitro cytotoxicity evaluation of some substituted isatin derivatives.
Results indicate that di- and tri-substituted isatins may be useful leads for anticancer drug development in the future.
Antioxidant and anticancer activities from aerial parts of Acalypha indica Linn
Extracts of Acalypha indica Linn. (aerial parts) were investigated for antioxidant activity, anticancer activity, and cytotoxicity. The extracts showed a non-cytotoxic response against Vero cells
Immunologically induced generation of tetraene and pentaene leukotrienes in the peritoneal cavities of menhaden-fed rats.
The finding that FFD favors the immunologic generation of LTB5, which has attenuated biologic activity when compared to LTB4, suggests that EPA-enriched tissues may produce less pro-inflammatory activity than tissues that are EPA-poor.
An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins.
A range of substituted N-alkylisatins were synthesized and their cytotoxicity evaluated against several cancer cell lines in vitro. SAR studies indicated that the introduction of an aromatic ring
N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents.
The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC(50) value of 0.19 microM.
Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.
The antiplasmodial test results, of the isolated alkaloid components, are commensurated with the ethnopharmacological uses of this plant.
Chemical Constituents and Antioxidant and Biological Activities of the Essential Oil from Leaves of Solanum spirale
The essential oil of the leaves Solanum spirale Roxb. was isolated by hydrodistillation and analyzed for the first time using GC and GC-MS. Thirty-nine constituents were identified, constituting
Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships.
The alkaloids reversed MDR via the inhibition of P-gp function, and may be introduced as potential candidate molecules for treating cancers exhibiting P- gp-mediated MDR.
Chemical constituents and biological activities of Garcinia cowa Roxb
Garcinia cowa is an abundant source of bioactive phytochemicals. Phytochemical investigations of the plant parts indicated that the fruit, twig and stem are the best source of secondary metabolites,
The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry
The bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids from the twigs of Jacaranda obtusifolia, demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50 values of 30.1 and 16.6 μg mL-1, respectively.