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PLINK: a tool set for whole-genome association and population-based linkage analyses.
Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to researchers. Many existing genetic-analysis tools are not designed to handle such large data setsExpand
Second-generation PLINK: rising to the challenge of larger and richer datasets
The second-generation versions of PLINK will offer dramatic improvements in performance and compatibility. Expand
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed aExpand
A second generation human haplotype map of over 3.1 million SNPs
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations andExpand
Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits
A website for performing power calculations for the design of linkage and association genetic mapping studies of complex traits. Expand
Analysis of protein-coding genetic variation in 60,706 humans
Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis ofExpand
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide associationExpand
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations betweenExpand
Variance components models for gene-environment interaction in twin analysis.
  • S. Purcell
  • Mathematics, Medicine
  • Twin research : the official journal of the…
  • 1 December 2002
Gene-environment interaction is likely to be a common and important source of variation for complex behavioral traits. Often conceptualized as the genetic control of sensitivity to the environment,Expand
Partitioning heritability by functional annotation using genome-wide association summary statistics
Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here we analyze a broad set of functional elements,Expand