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Lethal toxin of Bacillus anthracis causes apoptosis of macrophages.
Lethal toxin is a major anthrax virulence factor, causing the rapid death of experimental animals. Lethal toxin can enter most cell types, but only certain macrophages and cell lines are susceptibleExpand
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Secreted Neutral Metalloproteases of Bacillus anthracis as Candidate Pathogenic Factors*
To evaluate the pathogenic potential of Bacillus anthracis-secreted proteases distinct from lethal toxin, two neutral zinc metalloproteases were purified to apparent homogeneity from the cultureExpand
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Effect of Bacillus anthracis lethal toxin on human peripheral blood mononuclear cells
Lethal toxin (LeTx) plays a central role in anthrax pathogenesis, however a cytotoxicity of LeTx has been difficult to demonstrate in vitro. No cytolytic effect has been reported for human cells, inExpand
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Anaerobic induction of Bacillus anthracis hemolytic activity.
A number of genes in Bacillus anthracis encode for proteins homologous to the membrane-damaging factors known as pathogenic determinants in different bacteria. B. anthracis, however, has beenExpand
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Acceleration of epithelial cell syndecan-1 shedding by anthrax hemolytic virulence factors
BackgroundIt has been recently reported that major pathogens Staphylococcus aureus and Pseudomonas aeruginosa accelerate a normal process of cell surface syndecan-1 (Synd1) ectodomain shedding as aExpand
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Degradation of Circulating von Willebrand Factor and Its Regulator ADAMTS13 Implicates Secreted Bacillus anthracis Metalloproteases in Anthrax Consumptive Coagulopathy*
Pathology data from the anthrax animal models show evidence of significant increases in vascular permeability coincident with hemostatic imbalances manifested by thrombocytopenia, transientExpand
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Alteration in Superoxide Dismutase 1 Causes Oxidative Stress and p38 MAPK Activation Following RVFV Infection
Rift Valley fever (RVF) is a zoonotic disease caused by Rift Valley fever virus (RVFV). RVFV is a category A pathogen that belongs to the genus Phlebovirus, family Bunyaviridae. Understanding earlyExpand
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Bacillus anthracis co-opts nitric oxide and host serum albumin for pathogenicity in hypoxic conditions
Bacillus anthracis is a dangerous pathogen of humans and many animal species. Its virulence has been mainly attributed to the production of Lethal and Edema toxins as well as the antiphagocyticExpand
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Systemic cytokine response in murine anthrax
Systemic pro‐inflammatory cytokine release has been previously implicated as a major death‐causing factor in anthrax, however, direct data have been absent. We determined the levels of IL‐1β, IL‐6Expand
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Bacillus anthracis Interacts with Plasmin(ogen) to Evade C3b-Dependent Innate Immunity
The causative agent of anthrax, Bacillus anthracis, is capable of circumventing the humoral and innate immune defense of the host and modulating the blood chemistry in circulation to initiate aExpand
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