• Publications
  • Influence
Population-Based Mechanistic Prediction of Oral Drug Absorption
The bioavailability of drugs from oral formulations is influenced by many physiological factors including gastrointestinal fluid composition, pH and dynamics, transit and motility, and metabolism andExpand
  • 289
  • 21
Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties
The assessment of the torsadogenic potency of a new chemical entity is a crucial issue during lead optimization and the drug development process. It is required by the regulatory agencies during theExpand
  • 73
  • 5
International, Collaborative Experience of 1789 Patients Having Multifetal Pregnancy Reduction: A Plateauing of Risks and Outcomes
Objective: To develop the most up-to-date, complete data base of multifetal pregnancy reduction (MFPR) from cases, and to provide the best counseling for couples with multifetal pregnancies. Methods:Expand
  • 57
  • 2
KinetDS: An Open Source Software for Dissolution Test Data Analysis
Because drug quality is the focus for pharmaceutical industry and regulatory agencies, the in vitro dissolution test bec omes a standard tool for characterization of manufactured products. However,Expand
  • 56
  • 2
  • Open Access
Serum potassium, sodium and calcium levels in healthy individuals - literature review and data analysis.
PURPOSE The human body is known to be composed of 24 elements, among which potassium, sodium and calcium are considered to be essential. These necessary components play a significant physiologicalExpand
  • 24
  • 2
  • Open Access
Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: a case study using the BCS/BDDCS Class II
Quantitative prediction of food effects (FE) upon drug pharmacokinetics, including population variability, in advance of human trials may help with trial design by optimising the number of subjectsExpand
  • 31
  • 1
Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials
BackgroundProarrhythmia assessment is one of the major concerns for regulatory bodies and pharmaceutical industry. ICH guidelines recommending preclinical tests have been established in attempt toExpand
  • 34
  • 1
In vitro-in vivo extrapolation of drug-induced proarrhythmia predictions at the population level.
Drug cardiotoxicity is a serious issue for patients, regulators, pharmaceutical companies and health service payers because they are all affected by its consequences. Despite the wide range of dataExpand
  • 19
  • 1
The impact of pharmaceutical care on patients with hypertension and their pharmacists
Objective The purpose of the study was to assess the influence of pharmaceutical care on patients’ knowledge, quality of life and blood pressure and to determine whether new type of pharmaceuticalExpand
  • 19
  • 1
  • Open Access
Am I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity.
This review aims to present and compare various Torsade de pointes propensity classification schemes of drugs that are publicly available from many scientific sources. We have also tracked and listedExpand
  • 15
  • 1