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Integrative Clinical Genomics of Advanced Prostate Cancer
Effects of aerobic exercise on mild cognitive impairment: a controlled trial.
Six months of high-intensity aerobic exercise had sex-specific effects on cognition, glucose metabolism, and hypothalamic-pituitary-adrenal axis and trophic activity despite comparable gains in cardiorespiratory fitness and body fat reduction.
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant.
The data indicate that constitutively active AR splice variants can contribute to the development of castration-resistant prostate cancers and may serve as biomarkers for patients who are likely to suffer from early recurrence and are candidates for therapies directly targeting the AR rather than ligand.
Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.
These findings support an adaptive shift toward AR-V-mediated signaling in a subset of CRPC tumors as the AR-LBD is rendered inactive, suggesting an important mechanism contributing to drug resistance to CRPC therapy.
Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial.
These results support longer trials of intranasal insulin therapy for patients with amnestic mild cognitive impairment and patients with AD.
Resistance to CYP17A1 Inhibition with Abiraterone in Castration-Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants
It is indicated that abiraterone reduces CRPC growth via suppression of intratumoral androgens and that resistance to abIRaterone may occur through mechanisms that include upregulation of CYP17A1, and/or induction of AR and AR splice variants that confer ligand-independent AR transactivation.
The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms.
- C. Båvik, Ilsa M. Coleman, J. Dean, B. Knudsen, S. Plymate, P. Nelson
- Biology, MedicineCancer research
- 15 January 2006
The concept that aging-related changes in the prostate microenvironment may contribute to the progression of prostate neoplasia is supported.
Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study.
- G. Watson, B. Cholerton, S. Craft
- Medicine, PsychologyThe American journal of geriatric psychiatry…
- 1 November 2005
Preliminary support is provided that rosiglitazone may offer a novel strategy for the treatment of cognitive decline associated with AD, consistent with recent reports that plasma Abeta42 decreases with progression of AD.
Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases
A novel immunohistochemical approach was developed which was used to ascertain the prevalence of AR variants in a large number of primary PCa and metastatic CRPC tissues and showed a snapshot of overall high frequency of C-terminal truncated AR splice variants and site specific AR loss in CRPC, which could have utility in stratifying patients for AR targeted therapeutics.
Mechanisms of the androgen receptor splicing in prostate cancer cells
It is demonstrated that RNA splicing of AR-V7 in response to ADT was closely associated with AR gene transcription initiation and elongation rates and splicing factor recruitment to AR pre-mRNA under ADT conditions.