• Publications
  • Influence
Mitochondrial DNA mutations in human colonic crypt stem cells.
The mitochondrial genome encodes 13 essential subunits of the respiratory chain and has remarkable genetics based on uniparental inheritance. Within human populations, the mitochondrial genome has aExpand
  • 484
  • 18
  • PDF
Obstructive jaundice causes reduced expression of polymorphonuclear leucocyte adhesion molecules and a depressed response to bacterial wall products in vitro.
BACKGROUND--Obstructive jaundice is associated with an increased incidence of infection and endotoxaemia, which may result from impaired host immunity. Neutrophil adhesion to vascular endothelium isExpand
  • 26
  • 3
Physiological changes after Delorme's procedure for full‐thickness rectal prolapse
Anal sphincter pressures, rectal compliance and sensation in 19 women of mean age 77 (range 57–94) years were studied before and after Delorme's procedure for full‐thickness rectal prolapse. NoExpand
  • 46
  • 3
The quality of patient‐orientated internet information on colorectal cancer
Objective  The Internet provides an enormous amount of patient‐orientated information on colorectal cancer. This study examined its accessibility and quality.
  • 37
  • 2
Rectal Retroflexion: An Essential Part of Lower Gastrointestinal Endoscopic Examination
PURPOSE Retroflexion of the endoscope during rectal examination may increase diagnostic yield but is not routinely performed because of concerns about safety and a lack of appreciation of itsExpand
  • 36
  • 2
Improving care at scale: process evaluation of a multi-component quality improvement intervention to reduce mortality after emergency abdominal surgery (EPOCH trial)
BackgroundImproving the quality and safety of perioperative care is a global priority. The Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial was a stepped-wedge cluster randomisedExpand
  • 29
Glutaraldehyde as a possible cause of diarrhoea after sigmoidoscopy
An outbreak of proctitis at the start of a colorectal cancer screening programme utilizing flexible sigmoidoscopy prompted scrutiny of the incidence of this complication and the role ofExpand
  • 21
Rectal retroflexion
PURPOSE: Retroflexion of the endoscope during rectal examination may increase diagnostic yield but is not routinely performed because of concerns about safety and a lack of appreciation of itsExpand
  • 17
Fine-bore cannulas for peripheral intravenous nutrition: polyurethane or silicone?
The peripheral intravenous route is being used more frequently for the administration of short- to medium-term parenteral nutritional support. Dedicated fine bore cannulas have significantly reducedExpand
  • 10
Treatment of right hepatic artery injury by percutaneous embolisation
dyspnoea or hypotension. The patient began treatment with mecillinam 7 days before the start of these symptoms. Mecillinam and Venoferrum were discontinued and the patient recovered fully within 2Expand
  • 13