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Dose‐dependent attenuation of auditory phantom perception (tinnitus) by PET‐guided repetitive transcranial magnetic stimulation
Recent data suggest that chronic tinnitus is a “phantom auditory perception” caused by maladaptive neuroplasticity and subsequent hyperactivity in an extended neuronal network including the primaryExpand
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Principles of Local Drug Delivery to the Inner Ear
As more and more substances have been shown in preclinical studies to be capable of preventing damage to the inner ear from exposure to noise, ototoxic drugs, ischemia, infection, inflammation,Expand
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Distribution of Dexamethasone and Preservation of Inner Ear Function following Intratympanic Delivery of a Gel-Based Formulation
Intratympanic (IT) delivery of drugs to the ear is increasingly used for both clinical and research purposes. One limitation of IT delivery is that drugs are rapidly lost from the middle ear by aExpand
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Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic
To study the safety and efficacy of continuous intratympanic dexamethasone‐phosphate (Dex‐P) for severe to profound sudden idiopathic sensorineural hearing (ISSHL) or sudden idiopathic anacusis afterExpand
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Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: a randomised, controlled pilot study
Background: Tinnitus has been shown to respond to modulations of cortical activity by high-frequency and low-frequency repetitive transcranial magnetic stimulation (rTMS). Objective: To determine theExpand
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Correlation of nasal morphology and respiratory function.
In order to investigate the fluid dynamic preconditions that guarantee a sufficient contact of air with nasal mucosa, we studied flow patterns in modified "Mink's boxes" and in nasal models. As aExpand
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Treatment of chronic tinnitus with theta burst stimulation
Objective: To test whether 4 weeks of bilateral repetitive transcranial magnetic stimulation (rTMS) to the temporal or temporoparietal cortex is effective and safe in the treatment of chronicExpand
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Dexamethasone Concentration Gradients Along Scala Tympani After Application to the Round Window Membrane
Hypothesis: Local application of dexamethasone-21-dihydrogen-phosphate (Dex-P) to the round window (RW) membrane of guinea pigs produces a substantial basal-apical concentration gradient in scalaExpand
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Concentration Gradient Along the Scala Tympani After Local Application of Gentamicin to the Round Window Membrane
Objectives: The distribution of gentamicin along the fluid spaces of the cochlea after local applications has never previously been demonstrated. Computer simulations have predicted that significantExpand
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Local inner-ear drug delivery and pharmacokinetics.
Several drugs that are applied directly to the inner ear are in widespread clinical use for the treatment of inner-ear disorders. Many new substances and drug delivery systems specific to the innerExpand
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