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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
TLDR
It is shown that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier, which may represent the first example of a novel class of autoimmune channelopathy.
Revised diagnostic criteria for neuromyelitis optica
TLDR
Revised diagnostic criteria for definite neuromyelitis optica (NMO) that require optic neuritis, myelitis, and at least two of three supportive criteria: MRI evidence of a contiguous spinal cord lesion 3 or more segments in length, onset brain MRI nondiagnostic for multiple sclerosis, or NMO-IgG seropositivity.
Revised diagnostic criteria for neuromyelitis optica
TLDR
Revised diagnostic criteria for definite neuromyelitis optica (NMO) that require optic neuritis, myelitis, and at least two of three supportive criteria: MRI evidence of a contiguous spinal cord lesion 3 or more segments in length, onset brain MRI nondiagnostic for multiple sclerosis, or NMO-IgG seropositivity.
Brain abnormalities in neuromyelitis optica.
TLDR
MRI brain findings in NMO justify revision of diagnostic criteria for NMO to allow for brain involvement, and asymptomatic brain lesions do not exclude the diagnosis of NMO.
Steroid-responsive encephalopathy associated with autoimmune thyroiditis.
TLDR
Until the pathophysiologic mechanism of this and other autoimmune encephalopathies is better characterized, it is believed that descriptive terms that reflect an association rather than causation are most appropriate for this syndrome.
Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis.
TLDR
Findings strongly support a role for a complement activating AQP4-specific autoantibody as the initiator of the NMO lesion, and further distinguish NMO from MS.
Neuromyelitis optica and non organ-specific autoimmunity.
TLDR
Neuromyelitis optica spectrum disorders with seropositive findings for NMO-IgG occurring with SS/SLE or non-organ-specific autoantibodies is an indication of coexisting NMO rather than a vasculopathic or other complication of SS/ SLE.
Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression.
TLDR
The distribution of NMO-characteristic brain lesions corresponds to sites of high AQP4 expression in mammalian brain, and recurring and distinctive magnetic resonance imaging abnormalities in the hypothalamic and periventricular areas that corresponded to brain regions ofhigh AQP 4 expression are observed.
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