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Activation of sphingosine kinase 1 by ERK1/2‐mediated phosphorylation
Sphingosine kinase 1 is an agonist‐activated signalling enzyme that catalyses the formation of sphingosine 1‐phosphate, a lipid second messenger that has been implicated in a number of agonist‐drivenExpand
Regulation of sphingosine kinase and sphingolipid signaling.
  • S. Pitson
  • Biology, Medicine
  • Trends in biochemical sciences
  • 1 February 2011
Bioactive sphingolipids, including ceramide, sphingosine and sphingosine 1-phosphate are important regulators of many cellular processes, including cell survival, proliferation, differentiation,Expand
An oncogenic role of sphingosine kinase
Sphingosine kinase (SphK) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). S1P/SphK has been implicated as a signalling pathway to regulateExpand
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
Sphingosine kinase (SK) 1 catalyzes the formation of the bioactive lipid sphingosine 1-phosphate, and has been implicated in several biological processes in mammalian cells, including enhancedExpand
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling.
Tumor necrosis factor-alpha (TNF) receptor-associated factor 2 (TRAF2) is one of the major mediators of TNF receptor superfamily transducing TNF signaling to various functional targets, includingExpand
Noncellulolytic fungal β-glucanases : their physiology and regulation
The occurrence, regulation, and action of fungal enzymes capable of degrading noncellulosic β-glucans, especially 1,3-β- and 1,6-β-glucans, are reviewed. Special consideration is given to their rolesExpand
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate
Sphingosine kinase 1 (SK1) is an enzyme that catalyses the phosphorylation of sphingosine to produce the bioactive lipid sphingosine 1-phosphate (S1P). We demonstrate here that FTY720 (Fingolimod™)Expand
Sphingosine Kinase Modulates Microvascular Tone and Myogenic Responses Through Activation of RhoA/Rho Kinase
Background RhoA and Rho kinase are important modulators of microvascular tone. Methods and Results We tested whether sphingosine kinase (Sphk1) that generates the endogenous sphingolipid mediatorExpand
Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease
BackgroundThe accumulation of beta amyloid (Aβ) peptides, a hallmark of Alzheimer’s disease (AD) is related to mechanisms leading to neurodegeneration. Among its pleiotropic cellular effects, AβExpand
Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling*
Tumor necrosis factor-α (TNF) receptor-associated factor 2 (TRAF2) is one of the major mediators of TNF receptor superfamily transducing TNF signaling to various functional targets, includingExpand
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