• Publications
  • Influence
Cutaneous photodamage, oxidative stress, and topical antioxidant protection.
  • S. Pinnell
  • Medicine
  • Journal of the American Academy of Dermatology
  • 2003
UNLABELLED New methods to protect skin from photodamage from sun exposure are necessary if we are to conquer skin cancer and photoaging. Sunscreens are useful, but their protection is not idealExpand
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Evidence supporting zinc as an important antioxidant for skin
Antioxidants play a critical role in keeping skin healthy. The antioxidant benefits of vitamin C and E are well known, but the importance of the trace mineral, zinc, has been overlooked. This articleExpand
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Topical L‐Ascorbic Acid: Percutaneous Absorption Studies
BACKGROUND Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect skin from these insults. OBJECTIVE This studyExpand
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Regulation of collagen synthesis by ascorbic acid.
After prolonged exposure to ascorbate, collagen synthesis in cultured human skin fibroblasts increased approximately 8-fold with no significant change in synthesis of noncollagen protein. This effectExpand
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Topical vitamin C protects porcine skin from ultraviolet radiation‐induced damage
Summary Ultraviolet radiation damage to the skin is due, in part, to the generation of reactive oxygen species. Vitamin C (l‐ascorbic acid) functions as a biological co‐factor and antioxidant due toExpand
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Microfine zinc oxide (Z-cote) as a photostable UVA/UVB sunblock agent.
BACKGROUND Microfine zinc oxide (Z-Cote) is used as a transparent broad-spectrum sunblock to attenuate UV radiation (UVR), including UVA I (340-400 nm). OBJECTIVE Our purpose was to assess theExpand
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A heritable disorder of connective tissue. Hydroxylysine-deficient collagen disease.
Abstract Two sisters nine and 12 years of age presented with a similar clinical picture consisting of severe scoliosis, recurrent joint dislocation and hyperextensible skin and joints. Amino acid a...
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Ehlers-Danlos syndrome type VI: clinical manifestations of collagen lysyl hydroxylase deficiency.
We reviewed the clinical findings in 10 patients with lysyl hydroxylase deficiency (Ehlers-Danlos syndrome type VI) and report here the range of clinical severity in these patients. The distinctiveExpand
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Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts.
Effects of tranilast, N-(3,4-dimethoxycinnamoyl)anthranilic acid, on collagen synthesis in cultured human skin fibroblasts were studied. Tranilast was found to inhibit collagen synthesis in aExpand
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