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- Publications
- Influence
Cutaneous photodamage, oxidative stress, and topical antioxidant protection.
- S. Pinnell
- Medicine
- Journal of the American Academy of Dermatology
- 2003
UNLABELLED
New methods to protect skin from photodamage from sun exposure are necessary if we are to conquer skin cancer and photoaging. Sunscreens are useful, but their protection is not ideal… Expand
Evidence supporting zinc as an important antioxidant for skin
- E. Rostan, H. V. Debuys, D. Madey, S. Pinnell
- Medicine
- International journal of dermatology
- 1 September 2002
Antioxidants play a critical role in keeping skin healthy. The antioxidant benefits of vitamin C and E are well known, but the importance of the trace mineral, zinc, has been overlooked. This article… Expand
Topical L‐Ascorbic Acid: Percutaneous Absorption Studies
- S. Pinnell, H. Yang, +5 authors M. Levine
- Chemistry, Medicine
- Dermatologic surgery : official publication for…
- 1 February 2001
BACKGROUND Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect skin from these insults. OBJECTIVE This study… Expand
Regulation of collagen synthesis by ascorbic acid.
- S. Murad, D. Grove, K. A. Lindberg, G. Reynolds, A. Sivarajah, S. Pinnell
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 May 1981
After prolonged exposure to ascorbate, collagen synthesis in cultured human skin fibroblasts increased approximately 8-fold with no significant change in synthesis of noncollagen protein. This effect… Expand
Topical vitamin C protects porcine skin from ultraviolet radiation‐induced damage
- D. Darr, S. Combs, S. Dunston, T. Manning, S. Pinnell
- Chemistry, Medicine
- The British journal of dermatology
- 1 September 1992
Summary Ultraviolet radiation damage to the skin is due, in part, to the generation of reactive oxygen species. Vitamin C (l‐ascorbic acid) functions as a biological co‐factor and antioxidant due to… Expand
The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone.
- S. Pinnell, G. R. Martin
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 1 October 1968
Microfine zinc oxide (Z-cote) as a photostable UVA/UVB sunblock agent.
- M. A. Mitchnick, D. Fairhurst, S. Pinnell
- Medicine
- Journal of the American Academy of Dermatology
- 1999
BACKGROUND
Microfine zinc oxide (Z-Cote) is used as a transparent broad-spectrum sunblock to attenuate UV radiation (UVR), including UVA I (340-400 nm).
OBJECTIVE
Our purpose was to assess the… Expand
A heritable disorder of connective tissue. Hydroxylysine-deficient collagen disease.
- S. Pinnell, S. Krane, J. Kenzora, M. Glimcher
- Medicine
- The New England journal of medicine
- 11 May 1972
Abstract Two sisters nine and 12 years of age presented with a similar clinical picture consisting of severe scoliosis, recurrent joint dislocation and hyperextensible skin and joints. Amino acid a...
Ehlers-Danlos syndrome type VI: clinical manifestations of collagen lysyl hydroxylase deficiency.
- R. Wenstrup, S. Murad, S. Pinnell
- Medicine
- The Journal of pediatrics
- 1 September 1989
We reviewed the clinical findings in 10 patients with lysyl hydroxylase deficiency (Ehlers-Danlos syndrome type VI) and report here the range of clinical severity in these patients. The distinctive… Expand
Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts.
- H. Yamada, S. Tajima, T. Nishikawa, S. Murad, S. Pinnell
- Biology, Medicine
- Journal of biochemistry
- 1 October 1994
Effects of tranilast, N-(3,4-dimethoxycinnamoyl)anthranilic acid, on collagen synthesis in cultured human skin fibroblasts were studied. Tranilast was found to inhibit collagen synthesis in a… Expand