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Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
The renin–angiotensin system plays a critical role in blood pressure control and body fluid and electrolyte homeostasis. Besides angiotensin (Ang) II, other Ang peptides, such as Ang III [Ang-(2–8)],Expand
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Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney
It has been described recently that the nonpeptide AVE 0991 (AVE) mimics the effects of angiotensin-(1–7) [Ang-(1–7)] in bovine endothelial cells. In this study, we tested the possibility that AVE isExpand
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Impairment of In Vitro and In Vivo Heart Function in Angiotensin-(1-7) Receptor Mas Knockout Mice
In this study we investigated the effects of the genetic deletion of the angiotensin (Ang)-(1-7) receptor Mas on heart function. Localization of Mas in the mouse heart was evaluated by binding ofExpand
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Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs
The identification of novel biochemical components of the renin–angiotensin system (RAS) has added a further layer of complexity to the classical concept of this cardiovascular regulatory system. ItExpand
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The Antithrombotic Effect of Angiotensin-(1-7) Involves Mas-Mediated NO Release from Platelets
The antithrombotic effect of angiotensin(Ang)-(1-7) has been reported, but the mechanism of this effect is not known. We investigated the participation of platelets and receptor Mas-relatedExpand
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Characterization of a New Selective Antagonist for Angiotensin-(1–7), d-Pro7-Angiotensin-(1–7)
Abstract—Angiotensin-(1–7) [Ang-(1–7)] has biological actions that can often be distinguished from those of angiotensin II (Ang II). Recent studies indicate that the effects of Ang-(1–7) are mediatedExpand
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Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function.
The vasodilator/antiproliferative peptide angiotensin-(1-7) [ANG-(1-7)] is released into the corpus cavernosum sinuses, but its role in erectile function has yet to be defined. In this study, weExpand
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Circulating Renin Angiotensin System in Childhood Chronic Renal Failure: Marked Increase of Angiotensin-(1–7) in End-Stage Renal Disease
The aim of the present study was to evaluate plasma renin activity (PRA) and Angiotensin (Ang) levels [Ang I, Ang II and Ang-(1–7)] to examine the circulating Renin-Angiotensin System (RAS) in renalExpand
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Selective increase of angiotensin(1-7) and its receptor in hearts of spontaneously hypertensive rats subjected to physical training.
In the present study we investigated the effects of physical training on plasma and cardiac angiotensin(1-7) [Ang(1-7)] levels. In addition, possible changes in expression of the Ang(1-7) MasExpand
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The therapeutic potential of Angiotensin-(1-7) as a novel Renin-Angiotensin System mediator.
In this review, we show Angiotensin-(1-7) as a novel Renin Angiotensin System mediator that antagonizes cardiovascular and proliferative effects of Angiotensin II and exerts complex renal actions. WeExpand
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