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Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome
It is reported here that minus-strand deamination occurred over the length of the virus genome, preferentially at CCCA sequences, with a graded frequency in the 5′→3′ direction.
Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.
The characterization of sequential methicillin-resistant Staphylococcus aureus bloodstream isolates that developed resistance in a patient treated with a prolonged course of linezolid shows reversion to a susceptible phenotype associated with a loss of the T2500A mutation.
In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied viral dynamics…
HIV rebounds from latently infected cells, rather than from continuing low-level replication
- B. Joos, M. Fischer, H. Günthard
- BiologyProceedings of the National Academy of Sciences
- 28 October 2008
The results argue against persistence of ongoing low-level replication in patients on suppressive cART and demonstrate a surprisingly sustained evolutionary bottleneck induced by punctuated antiretroviral therapy.
Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype.
This isolate was characterized by determination of the number of mutant 23S rRNA copies, assessment of the stability of the resistant phenotype, and comparison of its growth characteristics with those of linezolid-susceptible S. aureus.
Genetic attributes of cerebrospinal fluid-derived HIV-1 env.
There are several genetic features that distinguish CSF- and plasma-derived HIV-1 populations, probably reflecting altered cellular entry requirements and decreased immune pressure in the CNS, and neurological impairment may be influenced by mutations within the viral V3 loop sequence.
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient
The absence of recrudescent HIV replication and waning HIV-specific immune responses five years after withdrawal of treatment provide proof of a clinical cure.
Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates
Current default implementations of co-receptor prediction algorithms are inadequate for predicting HIV X4 co- receptor usage in clinical samples, particularly those X4 phenotypes with low CXCR4 RLU signals.
A new perspective on V3 phenotype prediction.
- S. Pillai, B. Good, D. Richman, J. Corbeil
- BiologyAIDS research and human retroviruses
- 1 February 2003
This work aimed to produce a superior phenotypic classifier by applying modern machine learning (ML) techniques to the current database of V3 loop sequences with known phenotype, and trained classifiers along with sequence data are available for public use.
Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells
This work used a novel HIV reporter strain in primary CD4+ T cells and determined which latently infected cells are reactivatable by current candidate LRAs, and challenged the feasibility of ‘shock and kill’.