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Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome
HIV-1 deleted for the vif accessory gene encapsidates the cellular cytidine deaminase APOBEC3G. Upon infection, the encapsidated APOBEC3G induces G→A mutations in the viral reverse transcripts. TheExpand
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In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied viral dynamicsExpand
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Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.
Linezolid is an important therapeutic option for infections caused by resistant gram-positive bacteria. We report the characterization of sequential methicillin-resistant Staphylococcus aureus (MRSA)Expand
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HIV rebounds from latently infected cells, rather than from continuing low-level replication
Rapid rebound of plasma viremia in patients after interruption of long-term combination antiretroviral therapy (cART) suggests persistence of low-level replicating cells or rapid reactivation ofExpand
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Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates
Objective:Integrating CCR5 antagonists into clinical practice would benefit from accurate assays of co-receptor usage (CCR5 versus CXCR4) with fast turnaround and low cost. Design:Published HIVExpand
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Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype.
Linezolid is an important therapeutic option for treatment of infections caused by glycopeptide- and beta-lactam-resistant gram-positive organisms. Linezolid resistance is caused by mutations withinExpand
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A new perspective on V3 phenotype prediction.
The particular coreceptor used by a strain of HIV-1 to enter a host cell is highly indicative of its pathology. HIV-1 coreceptor usage is primarily determined by the amino add sequences of the V3Expand
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Genetic attributes of cerebrospinal fluid-derived HIV-1 env.
HIV-1 often invades the CNS during primary infection, eventually resulting in neurological disorders in up to 50% of untreated patients. The CNS is a distinct viral reservoir, differing fromExpand
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Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells
Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence of latently infected cells. The ‘shock and kill’ approach to a cure proposes to eliminate this reservoirExpand
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Reduced susceptibility to vancomycin influences pathogenicity in Staphylococcus aureus infection.
In the present study, we demonstrated the utility of the nonmammalian model system Galleria mellonella for studying the pathogenesis of Staphylococcus aureus infection. By use of clinical andExpand
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