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NMDA-dependent superoxide production and neurotoxicity
It is reported that O·- 2 is produced upon NMDA receptor stimulation in cultured cerebellar granule cells and the nitrone DMPO (5,5-dimethyl pyrroline 1-oxide), used as a spin trap, is more efficient than the nitric oxide synthase inhibitor, L-N G -nitroarginine, in reducing NMDA-induced neuronal death in these cultures.
5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: a new efficient phosphorylated nitrone for the in vitro and in vivo spin trapping of oxygen-centered radicals.
Using 2 as a spin trap, the production of superoxide has been clearly characterized during the reperfusion of ischemic isolated rat hearts and the DEPMPO-superoxide spin adduct was shown to be significantly more persistent than the DMPO--superoxidespin adduct.
Exercise‐induced oxidative–nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood–brain barrier leakage
It is suggested that intense exercise has the potential to increase blood–brain barrier permeability without causing structural brain damage subsequent to a free radical‐mediated impairment in dynamic cerebral autoregulation.
Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761).
- S. Pietri, E. Maurelli, K. Drieu, M. Culcasi
- Biology, MedicineJournal of Molecular and Cellular Cardiology
- 1 February 1997
Cardioprotective effects of therapeutically relevant doses of Ginkgo biloba extract and its terpenoid constituents appear to involve an inhibition of free radical formation rather than direct free radical scavenging.
Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.
The data show that TP53INP1 is a major actor of p53-driven oxidative stress response that possesses both a p 53-independent intracellular ROS regulatory function and a p52-dependent transcription regulatory function.
Plastid Alternative Oxidase (PTOX) Promotes Oxidative Stress When Overexpressed in Tobacco
- Eiri Heyno, Christine M Gross, C. Laureau, M. Culcasi, S. Pietri, A. Krieger-Liszkay
- Environmental Science, BiologyJournal of Biological Chemistry
- 9 September 2009
It is proposed that superoxide is produced by PTOZ in a side reaction and that PTOX can only act as a safety valve under stress conditions when the generated superoxide has been detoxified by an efficient antioxidant system.
Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons.
Functional muscle impairment in facioscapulohumeral muscular dystrophy is correlated with oxidative stress and mitochondrial dysfunction.
Nitric oxide, superoxide and peroxynitrite: Putative mediators of NMDA-induced cell death in cerebellar granule cells
Colitis and Colitis-Associated Cancer Are Exacerbated in Mice Deficient for Tumor Protein 53-Induced Nuclear Protein 1
It is demonstrated by electron spin resonance and spin trapping that colons derived from deficient mice produced more free radicals than those of the WT during colitis and that the basal blood level of the antioxidant ascorbate was decreased in Trp53inp1-deficient mice, suggesting a higher oxidative load in the latter.