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Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
TLDR
It is reported that the initial steps in postsynaptic differentiation and formation of an end-plate band require MuSK and rapsyn, but are not dependent on agrin or the presence of motor axons, while the subsequent stages of synaptic growth and maintenance require nerve-derived agrin, and a second nerve- derived signal that disperses ectopic post synaptic apparatus.
ES cell potency fluctuates with endogenous retrovirus activity
TLDR
A rare transient cell population within mouse ES and induced pluripotent stem (iPS) cell cultures that expresses high levels of transcripts found in two-cell (2C) embryos in which the blastomeres are totipotent is identified.
Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
TLDR
Results indicate that ISL1, by virtue of its requirement for the formation of dorsal mesenchyme, is necessary for the development of the dorsal exocrine pancreas, and also thatISL1 function in pancreatic endodermal cells is required for the generation of all endocrine islet cells.
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