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Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia
Central Hypersensitivity in Chronic Pain After Whiplash Injury
- M. Curatolo, S. Petersen‐Felix, L. Arendt-Nielsen, Carmela Giani, A. Zbinden, B. Radanov
- Medicine, BiologyThe Clinical journal of pain
- 1 December 2001
The authors found a hypersensitivity to peripheral stimulation in whiplash patients, which resulted from alterations in the central processing of sensory stimuli (central hypersensitivity), and was not dependent on a nociceptive input arising from the painful and tender muscles.
The analgesic effect of oral delta-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions
The Effect of N-Methyl-D-aspartate Antagonist (Ketamine) on Single and Repeated Nociceptive Stimuli: A Placebo-Controlled Experimental Human Study
- L. Arendt-Nielsen, S. Petersen‐Felix, M. Fischer, P. Bak, P. Bjerring, A. Zbinden
- Biology, PsychologyAnesthesia and analgesia
- 1 July 1995
It is concluded that ketamine inhibits central temporal summation in humans and has a marked hypoalgesic effect on high intensity nociceptive stimuli.
The nociceptive withdrawal reflex: Normative values of thresholds and reflex receptive fields
Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury.
Chronic pain after whiplash injury is associated with hypersensitivity of the central nervous system to peripheral stimulation, and central hypersensitivity as a determinant of neck pain is probably a dynamic condition that is influenced by the presence of a nociceptive focus.
Sensory Assessment of Regional Analgesia in Humans: A Review of Methods and Applications
The knowledge available in the field of sensory assessment of regional analgesia in humans is updated and methods that explore the activation of different nerve fibers, models that activate specific spinal cord mechanisms, and method that evaluate muscle and visceral pain are described and analyzed.
Development and pharmacokinetic characterization of pulmonal and intravenous delta-9-tetrahydrocannabinol (THC) in humans.
- M. Naef, S. Russmann, S. Petersen‐Felix, R. Brenneisen
- Medicine, BiologyJournal of pharmaceutical sciences
- 1 May 2004
The aim of the present study was to develop a physiologically compatible inhalation solution of delta-9-tetrahydrocannabinol (THC), and to compare the pharmacokinetic and analgesic properties of…
Anesthetic Depth Defined Using Multiple Noxious Stimuli during Isoflurane/Oxygen Anesthesia I. Motor Reactions
- A. Zbinden, M. Maggiorini, S. Petersen‐Felix, R. Lauber, D. Thomson, C. Minder
- Medicine, BiologyAnesthesiology
- 1 February 1994
Tetanic stimulation and, to some extent, trapezius squeeze are reproducible and noninvasive stimulation patterns that can be used as an alternative to skin incision when evaluating potency of an anesthetic agent.
Evidence, Mechanisms, and Clinical Implications of Central Hypersensitivity in Chronic Pain After Whiplash Injury
- M. Curatolo, L. Arendt-Nielsen, S. Petersen‐Felix
- Medicine, PsychologyThe Clinical journal of pain
- 1 November 2004
Central hypersensitivity may explain exaggerated pain in the presence of minimal nociceptive input arising from minimally damaged tissues and provide a common neurobiological framework for the integration of peripheral and supraspinal mechanisms in the pathophysiology of chronic pain after whiplash.