S. Pestka

Publications483
h-index80
Citations25,796
Highly Influential Citations747
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Interferons, interferon‐like cytokines, and their receptors
TLDR
This review summarizes the history of the purification of human IFNs and the key aspects of the current state of knowledge of humanIFN genes, proteins, and receptors and provides some new insights into the development of these proteins as major elements of innate immunity. Expand
Interleukin-10 and related cytokines and receptors.
TLDR
These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system and further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a range of diseases. Expand
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvIL-10. cmvIL-10 can bind to the human IL-10 receptor and can… Expand
Identification of the Functional Interleukin-22 (IL-22) Receptor Complex
TLDR
Sharing of the common IL-10R2 chain between the IL- 10 and IL-TIF receptor complexes is the first such case for receptor complexes with chains belonging to the class II cytokine receptor family, establishing a novel paradigm for IL-9-related ligands similar to the shared use of the gamma common chain by several cytokines. Expand
Interferons and their actions.
TLDR
One that the authors will refer to break the boredom in reading is choosing interferons and their actions as the reading material. Expand
Identification and functional characterization of a second chain of the interleukin‐10 receptor complex
TLDR
The CRFB4 chain, which is designated as the IL‐10R2 or IL‐ 10Rβ chain, serves as an accessory chain essential for the activeIL‐10 receptor complex and to initiate IL‐8‐induced signal transduction events. Expand
Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential.
TLDR
Because of the intricate involvement of several PRMT in cellular physiology, their inhibition may be fraught with unwanted side effects, Nevertheless, development of pharmaceutical agents to control PRMT functions could lead to significant new targets. Expand
The Interferons: 50 Years after Their Discovery, There Is Much More to Learn*
  • S. Pestka
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 13 July 2007
TLDR
This brief review focuses on the discovery and purification of interferons, cloning of human IFN-α andIFN-β, interferon receptors, activities and therapeutic uses of interFERons, and the side effects of interfering. Expand
PRMT7, a New Protein Arginine Methyltransferase That Synthesizes Symmetric Dimethylarginine*
TLDR
The cDNA for PRMT7, a recently discovered human protein-arginine methyltransferase (PRMT), was cloned and expressed in Escherichia coli and mammalian cells, demonstrating thatPRMT7 (like PRMT5) is a Type II methyl transferase capable of producing SDMA modifications in proteins. Expand
PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins*
TLDR
PRMT5 is the first example of a catalytic chain for a type II protein arginine N-methyltransferase that can result in the formation of symmetric dimethylarginine residues as observed previously in myelin basic protein, Sm small nuclear ribonucleoproteins, and other polypeptides. Expand
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