Interferons, interferon‐like cytokines, and their receptors
- S. Pestka, C. D. Krause, Mark Walter
- BiologyImmunological Reviews
- 1 December 2004
This review summarizes the history of the purification of human IFNs and the key aspects of the current state of knowledge of humanIFN genes, proteins, and receptors and provides some new insights into the development of these proteins as major elements of innate immunity.
Interleukin-10 and related cytokines and receptors.
- S. Pestka, C. D. Krause, D. Sarkar, M. Walter, Yufang Shi, P. Fisher
- BiologyAnnual Review of Immunology
- 19 March 2004
These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system and further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a range of diseases.
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
- S. Kotenko, S. Saccani, L. Izotova, O. Mirochnitchenko, S. Pestka
- BiologyProceedings of the National Academy of Sciences…
- 15 February 2000
We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvIL-10. cmvIL-10 can bind to the human IL-10 receptor and can…
Interferons and their actions.
- S. Pestka, J. Langer, K. Zoon, C. E. Samuel
- MedicineAnnual Review of Biochemistry
- 1987
One that the authors will refer to break the boredom in reading is choosing interferons and their actions as the reading material.
Identification and functional characterization of a second chain of the interleukin‐10 receptor complex
- S. Kotenko, C. D. Krause, L. Izotova, B. Pollack, Wei Wu, S. Pestka
- BiologyEMBO Journal
- 1 October 1997
The CRFB4 chain, which is designated as the IL‐10R2 or IL‐ 10Rβ chain, serves as an accessory chain essential for the activeIL‐10 receptor complex and to initiate IL‐8‐induced signal transduction events.
Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential.
- C. D. Krause, Zhi-Hong Yang, Young-sun Kim, Jin‐Hyung Lee, J. R. Cook, S. Pestka
- BiologyPharmacology and Therapeutics
- 2007
Identification of the Functional Interleukin-22 (IL-22) Receptor Complex
- S. Kotenko, L. Izotova, S. Pestka
- BiologyJournal of Biological Chemistry
- 26 January 2001
Sharing of the common IL-10R2 chain between the IL- 10 and IL-TIF receptor complexes is the first such case for receptor complexes with chains belonging to the class II cytokine receptor family, establishing a novel paradigm for IL-9-related ligands similar to the shared use of the gamma common chain by several cytokines.
The Interferons: 50 Years after Their Discovery, There Is Much More to Learn*
- S. Pestka
- BiologyJournal of Biological Chemistry
- 13 July 2007
This brief review focuses on the discovery and purification of interferons, cloning of human IFN-α andIFN-β, interferon receptors, activities and therapeutic uses of interFERons, and the side effects of interfering.
PRMT7, a New Protein Arginine Methyltransferase That Synthesizes Symmetric Dimethylarginine*
- Jin‐Hyung Lee, J. R. Cook, S. Pestka
- Biology, ChemistryJournal of Biological Chemistry
- 4 February 2005
The cDNA for PRMT7, a recently discovered human protein-arginine methyltransferase (PRMT), was cloned and expressed in Escherichia coli and mammalian cells, demonstrating thatPRMT7 (like PRMT5) is a Type II methyl transferase capable of producing SDMA modifications in proteins.
The Human Homologue of the Yeast Proteins Skb1 and Hsl7p Interacts with Jak Kinases and Contains Protein Methyltransferase Activity*
- B. Pollack, S. Kotenko, Wen He, L. Izotova, B. Barnoski, S. Pestka
- BiologyJournal of Biological Chemistry
- 29 October 1999
It is demonstrated that this protein, designated JBP1 (Jak-binding protein 1), and its homologues contain motifs conserved among protein methyltransferases, and suggests that protein methyl transferases may have a role in cellular signaling.
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