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Neuronal membrane cholesterol loss enhances amyloid peptide generation
- José Abad-Rodríguez, M. Ledesma, +6 authors C. Dotti
- Medicine, Biology
- The Journal of cell biology
- 6 December 2004
Recent experimental and clinical retrospective studies support the view that reduction of brain cholesterol protects against Alzheimer's disease (AD). However, genetic and pharmacological evidence… Expand
The role of seladin‐1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo
The cholesterol‐synthesizing enzyme seladin‐1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide‐dependent oxidoreductase and regulates responses to oncogenic and oxidative stimuli. It has… Expand
Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro.
Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during embryonic development. In the aged brain, however, BDNF levels are low,… Expand
Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice
Multiple sclerosis (MS) is an autoimmune chronic disease of the central nervous system (CNS) characterized by immune-mediated inflammation, demyelination and subsequent axonal damage. Gene expression… Expand
Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons
- M. Martín, L. Trovò, S. Perga, A. Sadowska, C. Dotti
- Biology, Medicine
- Neurobiology of Aging
- 1 May 2011
Aged neurons constitute an outstanding example of survival robustness, outliving the accumulation of reactive oxygen species (ROS) derived from various physiological activities. Since during aging… Expand
Loss of braking signals during inflammation: a factor affecting the development and disease course of multiple sclerosis.
BACKGROUND In a recent genome-wide transcriptional analysis, we identified a gene signature for multiple sclerosis (MS), which reverted back to normal during pregnancy. Reversion was particularly… Expand
Biological activity of glatiramer acetate on Treg and anti-inflammatory monocytes persists for more than 10years in responder multiple sclerosis patients.
Glatiramer acetate (GA) is a widely used treatment for multiple sclerosis (MS), with incompletely defined mechanism of action. Short-term studies suggested its involvement in the modulation of… Expand
Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson’s and Alzheimer’s Disease Patients
Parkinson’s disease (PD) is a neurodegenerative pathology characterized by the degeneration of midbrain dopamine neurons, whose development and maintenance in brain is related to the transcription… Expand
Acute‐phase proteins investigation based on lectins affinity capture prior to 2‐DE separation: Application to serum from multiple sclerosis patients
- A. Robotti, Massimo Natale, +5 authors A. Bertolotto
- Chemistry, Medicine
- 1 September 2010
Plasma acute‐phase proteins (APPs) glyco‐isoforms are important biomarkers of inflammatory processes such as those occurring in multiple sclerosis (MS). Specific analysis of these proteins is often… Expand
Vitamin D Binding Protein Isoforms and Apolipoprotein E in Cerebrospinal Fluid as Prognostic Biomarkers of Multiple Sclerosis
Background Multiple sclerosis (MS) is a multifactorial autoimmune disease of the central nervous system with a heterogeneous and unpredictable course. To date there are no prognostic biomarkers even… Expand