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Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
TLDR
It is shown that reoxygenation after prolonged hypoxia reduces the reactive oxygen species (ROS) threshold for the mitochondrial permeability transition (MPT) in cardiomyocytes and that cell survival is steeply negatively correlated with the fraction of depolarized mitochondria. Expand
Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore.
TLDR
It is shown that reoxygenation after prolonged hypoxia reduces the reactive oxygen species (ROS) threshold for the mitochondrial permeability transition (MPT) in cardiomyocytes and that cell survival is steeply negatively correlated with the fraction of depolarized mitochondria. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes
TLDR
It is proposed that myocyte NO produced by activation of the PI(3)K–Akt–endothelial NOS axis acts as a second messenger of stretch by enhancing RyRC activity, contributing to myocardial contractile activation. Expand
Dietary fish oil confers direct antiarrhythmic properties on the myocardium of rats.
TLDR
It is established that irrespective of any effects on blood pressure or platelet function in vivo, dietary fish oil directly affects myocardial properties which may contribute to observed clinical reductions in cardiac mortality associated with fish consumption. Expand
Cardiac Membrane Fatty Acid Composition Modulates Myocardial Oxygen Consumption and Postischemic Recovery of Contractile Function
TLDR
Dietary fish oil directly influenced heart function and improved cardiac responses to ischemia and reperfusion, and direct effects on myocardial function may contribute to the altered cardiovascular disease profile associated with fish consumption. Expand
PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDH.
TLDR
Manipulating the cardiac Mito membrane n-3-to-n-6 PUFA ratio shows that the activation of Ca2+-dependent PDH can be augmented when the n-4 to n-6PUFA ratio is low, or attenuated when this ratio is relatively high (n-3 PUFA-rich diet). Expand
Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue.
TLDR
Preoperative oral coenzyme Q(10) therapy in patients undergoing cardiac surgery increases myocardial and cardiac mitochondrial coen enzymes levels, improves mitochondrial efficiency, and increases myCardial tolerance to in vitro hypoxia-reoxygenation stress. Expand
Oxidation of myofibrillar proteins in human heart failure.
TLDR
It is demonstrated that oxidative/nitrosylative changes of actin and tropomyosin are largely increased in human failing hearts and are likely to contribute to the contractile impairment evident in end-stage HF. Expand
Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure
TLDR
Eleven studies in which CoQ10 was tested for an effect on exercise capacity showed a modest improvement in exercise capacity with CoQ 10 supplementation but five showed no effect. Expand
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