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Cytotoxicity of oxidation derivatives of cholesterol on cultured aortic smooth muscle cells and their effect on cholesterol biosynthesis.
Purified cholesterol showed no cytotoxic effect and minimal inhibition of cholesterol biosynthesis, while autooxidation products of cholesterol has the capability of inducing rabbits' aortic smooth cell death in vitro. Expand
Central nervous system vasculitis in cytomegalovirus infection
A 51-year-old man who received cyclophosphamide, vincristine, procarbazine and prednisone in the treatment of a small-cell undifferentiated lymphoma developed a rapidly progressive neurological syndrome characterized by a decline in alertness, deafness, blindness and paraplegia and died from terminal bronchopneumonia. Expand
Cholesterol oxidation derivatives and arterial endothelial damage.
Transmission electron-microscopic studies showed intracytoplasmic vacuoles and diffuse subendothelial edema in the aortae of the two groups receiving the oxidation derivatives of cholesterol. Expand
Biological Effects of Cholesterol Oxides
Introduction and Historical Perspective (C. Bruce Taylor and Shi-Kaung Peng). The Oxidation of Cholesterol (Leland L. Smith). Methods of Analysis of Cholesterol Oxides (Peter S.W. Park and Paul B.Expand
Angiotoxicity and atherogenicity of cholesterol oxides
An epidemiological study examining relationships between atherosclerosis and plasma levels of cholesterol oxides as independent risk factors may provide additional insights regarding the roles ofolesterol oxides in atherogenesis. Expand
Familial amyloid polyneuropathy
Immunochemical and immunocytochemical results support the concept that familial amyloid polyneuropathy with cardiomyopathy is due to infiltration of susceptible tissues by an anomalous transthyretin. Expand
Spontaneously occurring angiotoxic derivatives of cholesterol.
Effect of auto-oxidation products from cholesterol on aortic smooth muscle cells: an in vitro study.
The results showed that 25-hydroxycholesterol and cholestane-3beta, 5alpha, 6beta-triol were probably responsible for the biological toxicity of the concentrate, whereas purified cholesterol at the same concentration produced no toxic effects. Expand
Distribution of 25-hydroxycholesterol in plasma lipoproteins and its role in atherogenesis. A study in squirrel monkeys.
Oxidation products of cholesterol have been shown to be potent inhibitors of cholesterol biosynthesis and also highly toxic to cultured aortic smooth muscle cells and the possibility that plasma lipoproteins containing beta-apoprotein (i.e. LDL and VLDL) may carry more oxidation products than HDL which is not atherogenic. Expand
The role of cholesterol oxidation products in the pathogenesis of atherosclerosis.
  • R. Morin, S. Peng
  • Chemistry, Medicine
  • Annals of clinical and laboratory science
  • 1 July 1989
The cholesterol oxides appear to be transported in the blood primarily by very low density lipoproteins (VLDL). Expand