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GABAergic Circuits Control Spike-Timing-Dependent Plasticity
The spike-timing-dependent plasticity (STDP), a synaptic learning rule for encoding learning and memory, relies on relative timing of neuronal activity on either side of the synapse. GABAergicExpand
Key role of striatal cholinergic interneurons in processes leading to arrest of motor stereotypies.
Motor stereotypy is a key symptom of various disorders such as Tourette's syndrome and punding. Administration of nicotine or cholinesterase inhibitors is effective in treating some of theseExpand
Functional mu opioid receptors are expressed in cholinergic interneurons of the rat dorsal striatum: territorial specificity and diurnal variation
Striatal cholinergic interneurons play a crucial role in the control of movement as well as in motivational and learning aspects of behaviour. Neuropeptides regulate striatal cholinergic transmissionExpand
Cocaine‐induced stereotypy is linked to an imbalance between the medial prefrontal and sensorimotor circuits of the basal ganglia
The dysfunction of basal ganglia circuits related to stereotyped motor activity was analysed using the well‐established model of cocaine‐induced stereotypy in the rat. We examined and compared theExpand
Facilitation by Endogenous Tachykinins of the NMDA-Evoked Release of Acetylcholine after Acute and Chronic Suppression of Dopaminergic Transmission in the Matrix of the Rat Striatum
Using a microsuperfusion method in vitro, the effects of the NK1, NK2, and NK3 tachykinin receptor antagonists SR140333, SR48968, and SR142801, respectively, on the NMDA-evoked release ofExpand
μ opioid control of the N-methyl-d-aspartate-evoked release of [3h]-acetylcholine in the limbic territory of the rat striatum in vitro: diurnal variations and implication of a dopamine link
Using an in vitro microsuperfusion procedure, the release of newly synthesized [(3)H]-acetylcholine (ACh), evoked by N-methyl-D-aspartate (NMDA) receptor stimulation, was investigated inExpand
Region-specific and state-dependent action of striatal GABAergic interneurons
Striatum processes a wide range of functions including goal-directed behavior and habit formation, respectively encoded by the dorsomedial striatum (DMS) and dorsolateral striatum (DLS). GABAergicExpand
Tachykinin regulation of cholinergic transmission in the limbic/prefrontal territory of the rat dorsal striatum: implication of new neurokinine 1‐sensitive receptor binding site and interaction with
The tachykinin neurokinin 1 receptors (NK1Rs) regulation of acetylcholine release and its interaction with the enkephalin/mu opioid receptors (MORs) transmission was investigated in theExpand
Raclopride or high‐frequency stimulation of the subthalamic nucleus stops cocaine‐induced motor stereotypy and restores related alterations in prefrontal basal ganglia circuits
Motor stereotypy is a key symptom of various neurological or neuropsychiatric disorders. Neuroleptics or the promising treatment using deep brain stimulation stops stereotypies but the mechanismsExpand
Developmental control of spike-timing-dependent plasticity by tonic GABAergic signaling in striatum
Activity-dependent long-term potentiation (LTP) and depression (LTD) of synaptic strength underlie multiple forms of learning and memory. Spike-timing-dependent plasticity (STDP) has been describedExpand